UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CD19 — PIK3CA

Pathways - manually collected, often from reviews:

KEGG B cell receptor signaling pathway: CD19 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
NCI Pathway Database BCR signaling pathway: CD19 (CD19) → PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1) (modification, collaborate)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
NCI Pathway Database BCR signaling pathway: CD19 (CD19) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A) → PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1) (modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
NCI Pathway Database BCR signaling pathway: PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
NCI Pathway Database BCR signaling pathway: PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Inabe et al., Blood 2002 *

Text-mined interactions from Literome

Vigorito et al., J Immunol 2004 : By contrast, Vav function is essential for PI3K activation following membrane Ig (mIg)/CD19 coligation
Vigorito et al., Cell Signal 2006 : Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K , Vav1 and PLCgamma