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IL1A — PLD6
Text-mined interactions from Literome
Conquer et al., Osteoarthritis Cartilage 1994
:
Although PMA is known to stimulate phospholipase D ( PLD ) activity in most cells, it is not known whether LPS and
IL-1 also
stimulate PLD activity, or whether PLD activity contributes to AA liberation and PGE2 production in chondrocytes ... In the present study we compared the
effect of
IL-1 , LPS and protein kinase C ( PKC ) activators ( PMA ), mezerein, phorbol dibutyrate on PGE2 synthesis and
PLD activity in articular chondrocytes
Park et al., Mol Pharmacol 2002
:
The results of this study indicate that in human amnion cells,
IL-1 beta might
activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression
Bursten et al., Am J Physiol 1994
:
Evidence presented here indicates that stimulation of human mesangial cells by
IL-1 results in activation of a
phospholipase D ( PLD ) that hydrolyzes PE to phosphatidic acid ( PA )