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FGF2 — PDGFB

Pathways - manually collected, often from reviews:

• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → FGF2 (activation)
• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → PDGFB (activation)

Text-mined interactions from Literome

Wondergem et al., Atherosclerosis 2004 : Compared to cultures exposed to injury alone, radiation induced significant ( P < 0.05 ) increases in mRNA levels of IL-8 ( 1.35 +/- 0.10-fold increase at 4h ), FGF-2 ( 1.62 +/- 0.10-fold at 4h ; 1.76 +/- 0.33-fold at 24h ) and IL-1beta ( 2.76 +/- 0.40-fold at 24h ), whereas mRNA levels of TGF-beta1, PDGF-A and PDGF-B increased about 1.2-fold ... Compared to cultures exposed to injury alone, radiation induced significant ( P < 0.05 ) increases in mRNA levels of IL-8 ( 1.35 +/- 0.10-fold increase at 4h ), FGF-2 ( 1.62 +/- 0.10-fold at 4h ; 1.76 +/- 0.33-fold at 24h ) and IL-1beta ( 2.76 +/- 0.40-fold at 24h ), whereas mRNA levels of TGF-beta1, PDGF-A and PDGF-B increased about 1.2-fold
Millette et al., Circ Res 2005 : PDGF-BB induced the release of bFGF and sustained phosphorylation of FGFR-1 ( 30 minutes to 6 hours ) ... Our results provide support for a novel mechanism by which PDGF-BB induces the release of bFGF and activation of FGFR-1 followed by the sustained activation of ERK and proliferation of human SMCs
Kano et al., J Cell Sci 2005 : Experiments in vitro revealed that, in addition to having direct mitogenic effects, these molecules enhance intercellular PDGF-B signaling in a cell-type specific manner : VEGF-A enhances endothelial PDGF-B expression, whereas FGF-2 enhances mural PDGF receptor beta ( PDGFRbeta ) expression
Faraone et al., Blood 2006 : Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha : a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells
Reinmuth et al., Int J Oncol 2007 (Lung Neoplasms) : As determined by real-time PCR, both VEGF and bFGF induced a significant ( up to 4-fold ) increase in PDGF-B RNA expression which was time- and dose dependent ( p < 0.05 ) ... Using ELISA assays, VEGF and bFGF significantly increased PDGF-BB protein secretion in HUVECs ( p < 0.01 )
Van den Eynden et al., J Pathol 2007 (Breast Neoplasms...) : In involved LNs, the relative gene expression levels of PROX1 ( p < 0.001 ) and FGF2 ( p = 0.008 ) were decreased and the expression levels of VEGFA ( p = 0.01 ) and PDGFB ( p = 0.002 ) were increased compared to uninvolved LNs
Yamamoto et al., J Biol Chem 2008 : PDGF-AA induced the expression of the fibroblast growth factor genes Fgf3 and -7, and PDGF-BB induced the expression of Fgf1, -3, -7, and -10, whereas short interfering RNA for Pdgfa and Pdgfb inhibited the expression of Fgf3, -7, and -10, indicating that PDGFs regulate Fgf gene expression in SMG mesenchyme
Johnson et al., Exp Cell Res 1995 : In addition, specific binding of FGF2 to 48-h cultures of adult satellite cells was not stimulated by FGF2, IGF-1, IGF-2, PDGF-BB , or TGF-beta 2, and specific binding was significantly decreased ( P < 0.05 ) by FGF2 and TGF-beta 2
Rydziel et al., Endocrinology 1996 : In conclusion, normal Ob cells express the PDGF-B gene, and TGF beta 1 induces its transcription, whereas bFGF , IGF-I, and PDGF-BB do not enhance the levels of PDGF-B mRNA