Gene interactions and pathways from curated databases and text-mining

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NOS3 — VCAM1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: VCAM1 → NOS3 (increases, VCAM1 Activity)
    Evidence: L-NMA inhibited poly(I-C)-induced surface expression of E-selectin and VCAM-1 by 25 and 45%, respectively, and mRNA levels of E-selectin and VCAM-1

Text-mined interactions from Literome

Kawachi et al., Am J Physiol 1999 (Chronic Disease...) : Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation
Li et al., Arterioscler Thromb Vasc Biol 2002 (Hypertension) : The present study was undertaken to determine whether gene transfer of endothelial NO synthase (eNOS) or manganese superoxide dismutase ( MnSOD ) affects VCAM-1 levels in arteries from hypertensive rats ... These results suggest that gene transfer of MnSOD or eNOS suppresses arterial VCAM-1 expression in DOCA-salt hypertension by reducing the superoxide level
He et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 (Arteriosclerosis) : Compared with the model group, the expressions of integrins-beta1, CTGF and VCAM-1 were down-regulated and eNOS up-regulated in EECP group
Ponnuswamy et al., PloS one 2012 (Atherosclerosis) : eNOS deficiency increased macrophage infiltration in carotid arteries and vascular cell adhesion molecule-1 ( VCAM-1 ) expression, both in endothelial and smooth muscle cells