Gene interactions and pathways from curated databases and text-mining

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IL10 — PRKDC

Text-mined interactions from Literome

Yotsumoto et al., J Immunol 2008 : Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs dependent IL-10 production in macrophages ... Thus, our findings suggest that DNA-PKcs in the cytoplasm play an important role in CpG-ODN induced production of IL-10 in macrophages ... In addition, DNA-PKcs mediated production of IL-10 and IL-12 p70 can be regulated by manipulating the intracellular trafficking of CpG-ODN in macrophages
Hazeki et al., PloS one 2011 : Phosphoinositide 3-kinase? controls the intracellular localization of CpG to limit DNA-PKcs dependent IL-10 production in macrophages