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SRF — TGFB1
Text-mined interactions from Literome
Hirschi et al., J Biol Chem 2002
:
CArG motifs bind transcriptional activator serum response factor ; gel shift analyses revealed increased binding of
serum response factor containing complexes to this site in
response to
transforming growth factor-beta , paralleled by increased serum response factor protein expression
Yang et al., Am J Respir Cell Mol Biol 2003
:
cDNA array analysis showed that SRFDelta5 and
SRF induced expression of
transforming growth factor-beta1 , a critical factor in myofibroblast differentiation
Qiu et al., J Mol Cell Cardiol 2003
:
We found that
TGF-beta1 transiently
induces SRF and SM22 transcription, and that this process is accompanied by transient increases of SRF and Smad3 binding to the SM22 promoter
Kawai-Kowase et al., Arterioscler Thromb Vasc Biol 2004
:
TGFbeta1 increased
SRF expression through an increase in transcription of the SRF gene ... Transient transfection assays showed that bFGF significantly suppressed induction of the SM22alpha promoter-driven luciferase activity by TGFbeta1, whereas bFGF had no effects on the
TGFbeta1 mediated increase in SRF expression and
SRF : DNA binding activity
Sato et al., Arterioscler Thromb Vasc Biol 2005
:
PP1 also inhibited the
TGF-beta1 induced expression of
serum response factor (SRF) , a transcription factor regulating the SMC marker gene expression
Paradis et al., J Biol Chem 1996
:
Induction of the promoter by
transforming growth factor beta or norepinephrine
requires serum response factor (SRF) and TEF-1 ; expression is inhibited by YY1