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AHSA1 — VEGFA

Text-mined interactions from Literome

Rousseau et al., J Biol Chem 2000 : Using porcine endothelial cells expressing one or the other type of the VEGF receptors, VEGFR1 or VEGFR2, or human umbilical vein endothelial cells pretreated with a VEGFR2 neutralizing antibody, we show that VEGFR2 is responsible for VEGF induced activation of the stress activated protein kinase-2/p38 ( SAPK2/p38 ), phosphorylation of focal adhesion kinase ( FAK ), and enhanced migratory activity
Gratton et al., J Biol Chem 2001 : Blockade of PI 3-kinase/Akt also led to enhanced VEGF activation of p38 and apoptosis
Shemirani et al., Oral Oncol 2002 (Carcinoma, Squamous Cell...) : Overexpression of JNK1 or p38 was sufficient to induce HIF-1alpha and VEGF expression
Endo et al., J Recept Signal Transduct Res 2003 : Inhibition of VEGFR-2 blocked activation of extracellular regulated-kinase, p38 , Akt, and endothelial nitric oxide synthetase ( eNOS ) by VEGF , but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor ( PIGF )
McMullen et al., Oncogene 2004 : We investigated the molecular basis for p38 activation in response to VEGF
Nakagawa et al., American journal of physiology. Renal physiology 2004 (Anoxia) : Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted VEGF at 24 h, and this was significantly reduced by blocking Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Sudhakar et al., J Clin Invest 2005 (MAP Kinase Signaling System...) : In addition, alpha1 ( IV ) NC1 inhibited hypoxia induced expression of hypoxia-inducible factor 1alpha and VEGF in ECs cultured on type IV collagen by inhibiting ERK1/2 and p38 activation
Ferrari et al., Proc Natl Acad Sci U S A 2006 : In the absence of TGF-beta1, VEGF activates p38 ( MAPK ) and promotes endothelial cell survival ... However, in context with TGF-beta1, VEGF/flk-1 mediated activation of p38 ( MAPK ) results in apoptosis
Rocic et al., Am J Physiol Heart Circ Physiol 2007 (Disease Models, Animal...) : DPI and DETC blocked RI-induced p38 MAP kinase activation in response to vascular endothelial growth factor and RI
He et al., Mol Immunol 2007 (Inflammation...) : Furthermore, we show p38MAPK activation is necessary for increased VEGF and IL-8 secretion, NF-kappaB activation contributes to apoptosis resistance of human lung cancer cells induced by LPS
Bian et al., Exp Eye Res 2007 : Moreover, TGF-beta2 induced RPE VEGF secretion was significantly reduced by inhibitors of mitogen activated protein ( MAP ) kinase ( MEK ) ( U0126 ), p38 ( SB202190 ), c-Jun NH2-terminal kinase (JNK), Sp600125, protein tyrosine kinase ( PTK ) ( Genistein ), and phosphatidylinositol 3-kinase (PI3K) ( Ly294002 )
Raidl et al., Cell Biochem Biophys 2007 (Pulmonary Disease, Chronic Obstructive) : The effect of cigarette smoking on VEGF expression, the modulatory role of extracellular signal regulated kinase ( ERK ) -1,-2, p38mitogen activated protein kinase ( MAPK ), histone acetylation and the anti-inflammatory effect of dexamethasone on TNFalpha induced VEGF expression were examined in human airway smooth muscle cells ( HASMC ) of five non-smokers, 17 smokers without airflow limitation and 15 smokers with COPD
Gaundar et al., Cell cycle (Georgetown, Tex.) 2009 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : We have demonstrated that inhibition of p38 ( MAPK ) in bone marrow stromal cells reduced the production of IL-6, VEGF , PDGF and CXCL12
Morbidelli et al., Am J Physiol Regul Integr Comp Physiol 2010 : Initially, we observed that inhibition of sGC attenuated VEGF stimulated activation of p38
Umigai et al., Curr Neurovasc Res 2012 (Neovascularization, Pathologic) : The anti-angiogenic mechanism of crocetin was evaluated by examining its effects on VEGF induced proliferation and migration of human retinal microvascular endothelial cells ( HRMECs ) and phosphorylation of p38
Mima et al., FASEB J 2012 (Diabetic Nephropathies) : Elevation of glucose levels induced PKCd and p38 mitogen activated protein kinase ( p38 MAPK ) to increase SHP-1 expression, increased podocyte apoptosis, and inhibited VEGF activation in podocytes and glomerular endothelial cells
Li et al., Exp Cell Res 2012 : Taken together, VEGFR-2 is expressed on primary human hair follicle DP cells and VEGF induces proliferation of DP cells through VEGFR-2/ERK pathway, but not p38 , JNK or AKT signaling
Pin et al., Angiogenesis 2012 : In accordance, the VEGF induced activation of p38 and cell migration are impaired when the MKK3 expression is knocked down by siRNA
Wang et al., Mol Cell Biol 2013 (Disease Models, Animal...) : Upregulation of CD146 facilitated an endothelial response to VEGF induced SRC kinase family (SKF)/p38 mitogen activated protein kinase ( MAPK ) /NF-?B activation and consequently promoted endothelial cell migration and tube formation
Rousseau et al., Oncogene 1997 : p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells