Miyoshi et al., Mol Cell Endocrinol 2010
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Since the SAPK/JNK inhibitor inhibited FGF-8 effects in upregulating Id-1 transcription, SAPK/JNK appears to be involved in the mechanism by which FGF-8 enhances BMP-Smad signaling
Stuhlmiller et al., Development 2012
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Our results identify an early requirement for FGF/MAPK signaling in amniote neural crest induction and suggest an intriguing role for FGF mediated Smad inhibition in ectodermal development