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FGF8 — TBX1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Brown et al., Dev Biol 2004
:
This data is consistent with a model in which
Tbx1 induces
Fgf8 expression in the pharyngeal endoderm, which is subsequently required for normal cardiovascular morphogenesis and smooth muscle differentiation in the aorta and pulmonary artery
Goudy et al., Mech Dev 2010
(Cleft Palate) :
A sharp decrease of Fgf8 expression was detected in the Tbx1-/- palate shelves, suggesting that
Fgf8 is
dependent on
Tbx1 in the palate ... These data demonstrate that Tbx1 is a critical transcription factor that guides palatal elongation and elevation and that
Fgf8 expression in the palate is
Tbx1 dependent
Vitelli et al., J Mol Cell Cardiol 2010
:
Tbx1 regulates
Fgf8 expression hence the hypothesis that the proliferation impairment may contribute to the heart phenotype of mutants
Janesick et al., Development 2012
:
In the absence of RIPPLY3,
TBX1 is
required for the expression of
Fgf8 and hence, PPE formation