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LEP — PRL

Text-mined interactions from Literome

Watanobe et al., Biochem Biophys Res Commun 1999 : We have previously reported that leptin , the product of the obese ( ob ) gene, may play a physiologically relevant role in the generation of estradiol/progesterone induced luteinizing hormone ( LH ) and prolactin (PRL) surges in female rats
Gualillo et al., Endocrinology 1999 (Hyperprolactinemia) : Prolactin stimulates leptin secretion by rat white adipose tissue ... As PRL is involved in energy and lipid metabolism, this study was undertaken to investigate the role of PRL on in vivo regulation of leptin serum concentration and Ob messenger RNA expression in white adipose tissue in rats ... This stimulatory effect of PRL on serum leptin levels was significantly reduced by food deprivation ( P < 0.01 ) where serum leptin levels were 12.5+/-0.65 microg/liter in grafted animals vs. 3.2+/-0.36 microg/liter of grafted animals subjected to 48 h of food deprivation
Ling et al., Endocrinology 2001 : PRL receptor mediated effects in female mouse adipocytes : PRL induces suppressors of cytokine signaling expression and suppresses insulin induced leptin production in adipocytes in vitro ... In addition, the direct effect of PRL on leptin production was investigated in adipocytes cultured in vitro for 6 h. PRL inhibited insulin induced leptin production in vitro ... However, PRL had no effect on leptin production in the absence of insulin
Watanobe et al., J Neurochem 2003 : Thus, in this study we examined the involvement of several important PRL regulators in the leptin induced PRL secretion in male rats ... Results of dopamine and serotonin turnover studies in the brain and the pituitary indicated that neither of these biogenic amines plays a primary role in mediating leptin 's effects on PRL ... However, both the blockade of the melanocortin (MC) 4 receptor ( R ) and the immunoquenching of brain alpha-melanocyte stimulating hormone ( alpha-MSH ) completely abolished the leptin induced PRL release, and the stimulation of the MC4-R, but not the MC3-R, significantly elevated PRL levels in the fasted rats
Tanaka et al., Int J Mol Med 2003 : No effects of leptin on cell viability and prolactin secretion were found in unstimulated endometrial stromal cells ... As for 8-Br-cAMP stimulated cells, leptin significantly enhanced their cell viability in a dose dependent manner but not their PRL secretion
Steiner et al., Endocr Res 2003 : While neither fasting nor fasting plus leptin caused changes in serum prolactin , the increase in prolactin mRNA seen in fasted animals was prevented by leptin treatment
Feuermann et al., J Dairy Sci 2004 : Expression of leptin in tissue culture from mammary glands of lactating cows was enhanced 2.2-fold by prolactin ... No effect of prolactin on leptin and leptin receptor expression was found in mammary gland tissue culture from calves ... Our findings indicate that leptin plays an important role in mammary gland lactogenesis, and that the expression of leptin requires the presence of prolactin
Viengchareun et al., J Mol Endocrinol 2004 : However, PRL combined with insulin significantly increases leptin expression and release, indicating that PRL potentiates the stimulatory effect of insulin as revealed by the recruitment of insulin receptor substrates and the activation of phosphatidylinositol 3-kinase
Yonekura et al., Domest Anim Endocrinol 2006 : We examined the effect of growth hormone (GH) and/or lactogenic hormone complex ( DIP ; dexamethasone, insulin and prolactin ) on leptin mRNA expression in mammary epithelial cells
Feuermann et al., J Endocrinol 2006 : In the present study, we show that leptin is secreted from the mammary fat, and is regulated by prolactin
Tennekoon et al., Fertil Steril 2007 : Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells ... To study the possible effect of leptin on PRL and insulin-like growth factor (IGF)-I secretion from rat endometrial stromal cells ... The effect of recombinant murine leptin on the secretion of PRL and IGF-I by cultured rat endometrial cells was investigated ... Leptin also increased PRL secretion in a time dependent manner and the increase was seen at 24, 48, and 72 hours
Accorsi et al., J Dairy Sci 2007 : Role of leptin on growth hormone and prolactin secretion by bovine pituitary explants ... The results suggest that GH and PRL secretion in bovine pituitary explants can be directly regulated by leptin
Brandebourg et al., Biochem Biophys Res Commun 2007 : PRL also inhibited leptin , but not adiponectin, release ... We conclude that PRL inhibits lipolysis and leptin release by acting directly on adipocytes via interaction with either of its receptors and activation of a Jak2 dependent signaling pathway ( s )
Roy et al., J Endocrinol 2007 : PRL may also act through the inhibition of anorexigenic effect of leptin via induction of suppressor of cytokine signaling 3 ( SOCS-3 )
Tipsmark et al., J Endocrinol 2008 : Leptin stimulates pituitary prolactin release through an extracellular signal regulated kinase dependent pathway ... This study was carried out to examine the possible role of leptin in regulating prolactin (PRL) release using the teleost pituitary model system ... The rostral pars distalis were dissected from tilapia pituitaries and exposed to varying concentrations of leptin ( 0, 1, 10, 100 nM ) for 1 h. Release of PRL was stimulated by leptin in a potent and concentration dependent manner ... Many of the actions of leptin are mediated by the activation of extracellular signal regulated kinase ( ERK1/2 ) but nothing is known about the cellular mechanisms by which leptin might regulate PRL secretion in vertebrates ... We therefore tested whether ERK1/2 might be involved in the leptin PRL response and found that the ERK inhibitor, PD98059, hindered leptin induced PRL release
Feuermann et al., International journal of endocrinology 2009 : We also showed that after prolactin stimulate the secretion of leptin from the mammary fat, leptin upregulated the expression of estrogen receptor alpha in the mammary epithelial cells
Lisboa et al., Horm Metab Res 2010 (Hypothyroidism...) : We studied the effects of prolactin (PRL) inhibition during mid-lactation ( a partial malnutrition model ) on milk leptin transfer, leptinemia, body composition, and thyroid function
Kohsaka et al., Biochem Biophys Res Commun 1999 (Obesity) : A significant role of leptin in the generation of steroid induced luteinizing hormone and prolactin surges in female rats