Gene interactions and pathways from curated databases and text-mining

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MMP28 — SLC22A3

Text-mined interactions from Literome

Illman et al., J Cell Sci 2006 (Lung Neoplasms...) : Current results indicate that epilysin can induce EMT and cell invasion through a TGF-beta dependent mechanism suggesting novel biological roles for this enzyme in the regulation of epithelial cell function and in the induction of carcinogenesis
Stallings-Mann et al., Cells Tissues Organs 2007 (Cell Transformation, Neoplastic) : We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in MMP induced EMT
Lee et al., Carcinogenesis 2008 (Breast Neoplasms...) : Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP dependent mechanism
Illman et al., Exp Dermatol 2008 : Current results suggest a plausible interaction between epilysin and TGF-beta also under physiological circumstances, where epilysin activity may not induce EMT but, instead, trigger less permanent changes in TGF-beta signalling and cell motility
Tan et al., Am J Pathol 2010 (Fibrosis...) : AMCM induced tubular cell EMT in C1.1 cells was inhibited by broad-spectrum MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... Furthermore, MMP-9 induced tubular cell EMT in C1.1 cells to an extent similar to transforming growth factor-beta