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IRF6 — NFKBIB

Text-mined interactions from Literome

Medvedev et al., J Immunol 2000 (MAP Kinase Signaling System) : Pretreatment of mouse macrophages with LPS inhibited phosphorylation of the extracellular signal regulated kinases, c-Jun NH2-terminal kinases, and p38 kinase ; degradation of I-kappaBalpha ( inhibitory protein that dissociates from NF-kappaB ) and I-kappaBbeta ; and activation of the transcription factors NF-kappaB and AP-1 in response to subsequent LPS stimulation
Koo et al., Planta Med 2001 : CTN also significantly inhibited LPS induced DNA binding activity of NF-kappa B as well as the LPS induced degradation of I kappa B-alpha and -beta
De Plaen et al., Immunology 2002 : These observations suggest that LPS causes slow degradation and synthesis of IkappaBalpha and IkappaBbeta and therefore activates NF-kappaBeta via at least two mechanisms : initially, through an IkappaB independent mechanism, and later, via an increased turnover of the inhibitor IkappaB
Olsen et al., Int J Cancer 2004 (Carcinoma, Non-Small-Cell Lung...) : Moreover, CHS 828 has also been shown to inhibit the LPS induced degradation of the I kappa B alpha and I kappa B beta in THP-1 cells, leading us to identify the I kappa B kinase complex as a molecular target of CHS 828
Shimomura-Shimizu et al., Biochem Biophys Res Commun 2005 : LPS induced nuclear translocation of NF-kappaB, which is necessary for the expression of IFN-beta and iNOS, was inhibited by these chemicals : however, the LPS induced degradation of IkappaB-alpha and IkappaB-beta was inhibited only by alachlor
Campa et al., Inflamm Res 2005 (Inflammation) : Thus, poly I induced an increase in nuclear factor kappaB (NF-kappaB) transcriptional activity due to a long-term degradation of inhibitory NF-kappaB (IkappaB) beta while lipopolysaccharide (LPS) induced the degradation of both IkappaBalpha and IkappaBbeta
Souvannavong et al., Infect Immun 2007 : Immunoblotting analyses showed that LPS induced a time dependent degradation of the NF-kappaB inhibitors IkappaBbeta and IkappaBepsilon ( preferentially to isoform IkappaBalpha ), via IkappaB kinase beta
Haas et al., J Leukoc Biol 1998 : Exposure of human monocytic THP-1 cells to ALLN and Mu873 prevented the LPS induced degradation of IkappaB-alpha and -beta , as did the more potent proteasome inhibitor, PSI, whereas several calpain inhibitors were ineffective ... In primary human blood monocytes ALLN also prevented the LPS induced degradation of IkappaB-alpha and -beta , efficiently blocked the production of TNF and, to a lesser extent, IL-1beta, whereas that of IL-8 was not inhibited
Zen et al., Exp Cell Res 1998 : LPS induced IkappaBalpha degradation at 30-60 min after treatment, but did not induce IkappaBbeta degradation up to 120 min
Manna et al., J Immunol 1999 : Within minutes, LPS through CD14 induced the activation of NF-kappaB, degradation of IkappaBalpha ( inhibitory subunit of NF-kappaB ) and IkappaBbeta , and nuclear translocation of p65