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CYLD — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
CYLD (CYLD)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Jono et al., J Biol Chem 2004
(Inflammation) :
The present study revealed a novel autoregulatory feedback pathway through which activation of NF-kappaB by
TNF-alpha and bacterium nontypeable Haemophilus influenzae ( NTHi )
induces CYLD that in turn leads to the negative regulation of NF-kappaB signaling ... In addition, TRAF2 and TRAF6 appear to be differentially involved in NF-kappaB dependent
induction of
CYLD by
TNF-alpha and NTHi
Fukuda et al., Oncol Rep 2008
(Carcinoma, Adenoid Cystic...) :
The expression of
CYLD and NF-kappaB mRNAs in HSG cells was
increased by
TNF-alpha
Cui et al., Biochem Biophys Res Commun 2009
(Glomerulonephritis, IGA...) :
In cultured human tubular epithelial HK-2 cells,
tumor necrosis factor-alpha (TNFalpha)
up-regulated CYLD expression