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ABL1 — BCL2
Text-mined interactions from Literome
Horita et al., J Exp Med 2000
(Blast Crisis...) :
Here, we show that the interleukin 3-independent expression of the antiapoptotic protein,
Bcl-xL , is
induced by
Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5
Keeshan et al., Leukemia 2001
:
Despite the drug-resistant phenotype, high
Bcr-Abl levels concomitantly
increased the expression of p53, p21, Bax and down-regulated
Bcl-2
Sánchez-García et al., J Mol Biol 1997
(Cell Transformation, Neoplastic...) :
Regulation of
Bcl-2 gene expression by
BCR-ABL is mediated by Ras
Chen et al., Oncogene 1997
:
Here we demonstrate that
v-Abl PTK activation is
followed by an approximately twofold increase in mRNA level of
Bcl-XL by 6 h and a corresponding increase in Bcl-XL protein level by 24 h. Bcl-xL RNA and protein decreased in IL-3 deprived cells in the absence of v-Abl PTK activity