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Text-mined interactions from Literome

Rao et al., J Biol Chem 1999 : Both NAC and DPI completely inhibited agonist induced AP-1 activity and DNA synthesis in VSMC ... To understand the role of redox-sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth, we have studied the effect of N-acetylcysteine (NAC) , a thiol antioxidant, and diphenyleneiodonium ( DPI ), a potent NADH/NADPH oxidase inhibitor, on serum-, platelet derived growth factor BB-, and thrombin induced ERK2, JNK1, and p38 mitogen activated protein ( MAP ) kinase activation ; c-Fos , c-Jun, and JunB expression ; and DNA synthesis ... NAC inhibited agonist induced ERK2, JNK1, and p38 MAP kinase activation and c-Fos , c-Jun, and JunB expression except for platelet derived growth factor BB-induced ERK2 activation
Junn et al., J Immunol 2000 : NAC also reduced TGF-beta1 induced AP-1 binding activity, which is involved in IL-6 gene expression
Yamakawa et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : Induction of c-fos expression and enhanced AP-1 binding activity by lysoPC were also inhibited by DPI and NAC
Wu et al., Am J Respir Cell Mol Biol 2002 (MAP Kinase Signaling System) : In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC
Jafari et al., Respirology 2004 (Respiratory Distress Syndrome, Adult) : NAC blocked stretch induced NF-kappa B and AP-1 binding and inhibited IL-8 mRNA expression
Yang et al., Cancer Res 2005 (Adenocarcinoma...) : In the present study, we show that PEITC-NAC also induces apoptosis and AP-1 activity in human lung adenocarcinoma A549 cells, and that activation of AP-1 is important in PEITC-NAC induced apoptosis in these cells ... PEITC-NAC induced AP-1 binding activity in A549 cells in a dose- and time dependent manner ; peak activity appeared at 10 micromol/L after 24 hours
Li et al., Zhonghua Yi Xue Za Zhi 2005 : U0126, irbesartan, and NAC , as well as ACEUI, significantly inhibited the increased AP-1 DNA binding activity induced by Ang II ... U0126 and NAC significantly and NAC partly inhibited the increased AP-1 DNA binding activity induced by Aldo
Mackenzie et al., Free radical research 2006 (Neuroblastoma) : Consistent with this, LA and NAC prevented zinc deficiency induced activation of the early steps of NF- kappaB ( IkappaBalpha phosphorylation ) and AP-1 [ c-Jun-N-terminal kinase (JNK) and p38 phophorylation ] cascades, and the high NF-kappaB- and AP-1-DNA binding activities in total cell extracts
Kim et al., Biosci Biotechnol Biochem 2007 (Colorectal Neoplasms) : None of the dietary factors suppressed EGCG induced hydrogen peroxide generation in the media tested, whereas BITC, GA, and NAC inhibited the EGCG enhanced activator protein (AP)-1 transcription activity by 126 %, 77 %, and 97 %, respectively
Shyu et al., Clin Sci (Lond) 2012 : The gel shift and promoter activity assay showed that Ang II increased AP-1 ( activator protein-1 ) -binding activity and leptin promoter activity, while SP600125, NAC and atorvastatin inhibited the AP-1 binding activity and leptin promoter activity induced by Ang II
Kamata et al., J Biol Chem 1996 : NAC suppressed NGF induced c-fos gene expression and AP-1 activation
Wispriyono et al., J Pharmacol Exp Ther 1998 : One mM NAC also suppressed Cd-induced increase of c-Fos protein although NAC alone did not change the protein content