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FOS — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kirch et al., Oncogene 1999
:
Expression of human
p53 requires synergistic activation of transcription from the p53 promoter by
AP-1 , NF-kappaB and Myc/Max
Jiang et al., Oncogene 2001
(Stomach Neoplasms) :
Functional
p53 is
required for triptolide induced apoptosis and
AP-1 and nuclear factor-kappaB activation in gastric cancer cells
Ahn et al., Cancer Lett 2002
(Skin Neoplasms) :
Inhibitory effect of glycolic acid on ultraviolet B-induced c-fos expression,
AP-1 activation and
p53-p21 response in a human keratinocyte cell line
Vyas et al., Mol Cell Neurosci 2002
(Neurodegenerative Diseases) :
Our results indicate that prolonged
c-Fos induction
activates p53
Sun et al., J Cell Biochem 2004
:
We also demonstrate that both p300 and TATA box binding proteins cooperated with the transcription factor AP-1 to induce the promoter of MMP1 ; however,
p53 only inhibited the p300 mediated induction of the MMP1 promoter and the inhibition was
-72AP-1 dependent
Casamassimi et al., Cancer Res 1998
:
Fra-1 and c-jun were
induced by
p53 , resulting in increased
AP-1 levels