Gene interactions and pathways from curated databases and text-mining

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TNF — TNFRSF1B

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Santini et al., Haematologica 1999 (Leukemia, Myeloid, Acute) : We present here evidence that the sole stimulation of CD 120a, but not of CD120b , by TNF-alpha is responsible for bot monocytic maturation and apoptosis of primary AML blasts
Corti et al., Infect Immun 1999 (Tuberculosis) : Overall, these observations suggest that upregulation of TNF-RII or sTNF-RII contributes to modulation of the TNF-alpha antibacterial activity in MAC infections
Shlopov et al., Arthritis Rheum 2000 (Osteoarthritis) : In response to TNFalpha stimulation, messenger RNA ( mRNA ) levels for the IL-1 receptor I (IL-1RI), IL-1RII, TNF receptor II (TNFR II) , and IL-6 receptor as well as the level of proinflammatory cytokines, such as IL-1alpha, IL-1beta, lymphotoxin beta, TNFalpha, and IL-6, also increased
Abu-Amer et al., J Biol Chem 2000 : Reflecting its preferential activation of p55r, exogenous TNF stimulates osteoclast formation by p55r ( +/+ ) p75r ( -/- ), but not p55r ( -/- ) p75r ( +/+ ), marrow
Gaeta et al., Lab Invest 2000 : Unexpectedly, TNF responses were also inhibited by overexpressed TNFR1 and TNFR2 ( +DD ), but not TNFR2
Johnson et al., Ann Pharmacother 2001 : Etanercept inhibits the activity of tumor necrosis factor and lymphotoxin-alpha
Lung et al., Life Sci 2001 : The induction of TNF-R2 gene expression by TNF-alpha was dose dependent and seemed to be unique to TNF-alpha, as interleukin-6 (IL-6) had no significant effect on TNF-R2 expression
Hostager et al., J Immunol 2002 : Here we demonstrate that CD40 induced TNF stimulates IgM production through CD120b and that CD120b signaling is required for optimal CD40 induced IgM secretion
Moreland et al., Clin Immunol 2002 (Arthritis, Rheumatoid...) : Etanercept , a recombinant human tumor necrosis factor (TNF) inhibitor that binds both soluble and cell bound TNF, has been shown to reduce disease activity and inhibit joint destruction when administered to patients with rheumatoid arthritis ( RA )
Marriott et al., Clin Exp Immunol 2002 (Inflammation...) : Co-stimulation, but not the early inhibitory effect on TNFR2 , was IL-2 dependent and led to increased TNF-alpha production by both CD4+ and CD8+ T lymphocytes
Chen et al., J Appl Physiol 2003 : The enhancing effect of TNF-alpha on carbachol induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2
Goffe et al., J Am Acad Dermatol 2003 (Arthritis, Psoriatic) : Etanercept , a competitive inhibitor of TNF-alpha , is currently FDA approved for psoriatic arthritis and rheumatoid arthritis
Chen et al., FASEB J 2003 (MAP Kinase Signaling System) : Our data demonstrate that excessive TNF-alpha stimulates TNF-RII and enhances migration of ESCs in vitro
Strober et al., J Drugs Dermatol 2004 (Arthritis, Psoriatic...) : Etanercept is a human fusion protein of the tumor necrosis factor receptor (TNFR) and the Fc region of IgG1 that binds to and presumably inhibits the pro-inflammatory and pro-proliferative activity of the tumor necrosis factor (TNF)
Zheng et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2004 : Antibody blocking test and RT-PCR were used to evaluate the role of ICAM-1 and VCAM-1 in the cytotoxicity of TM-TNF-alpha mediated by TNFR I or TNFR II
Takada et al., J Immunol 2004 : Immunoprecipitation of cells with Syk Abs showed TNF dependent association of Syk with both TNFR1 and TNFR2 ; this association was enhanced by up-regulation of Syk expression with Syk-cDNA and suppressed by down-regulation of Syk using siRNA-Syk
Chen et al., Exp Cell Res 2004 : Autocrine TNF-alpha acts through TNFRII receptors to stimulate proliferation
Leng et al., Neurosci Lett 2005 (Chronic Disease...) : In contrast to TNF-alpha deficiency neither TNFR1 nor TNFR2 gene ablation showed protection against MPTP neurotoxicity, which argues for a protective mechanism of TNF-alpha not mediated by TNFR1 and TNFR2 signaling
Konnai et al., Virology 2005 (Disease Progression...) : Additionally, there were significant positive correlations between the changes in provirus load and TNF-RII mRNA levels, and TNF-alpha induced proliferation and TNF-RII mRNA levels
Wozel et al., Hautarzt 2005 (Arthritis, Psoriatic...) : Etanercept , an inhibitor of TNF alpha , has been found effective in the treatment of psoriatic arthritis and psoriasis vulgaris
Lin et al., J Allergy Clin Immunol 2006 (Common Variable Immunodeficiency...) : Etanercept prevents soluble TNF from binding to its cell membrane receptor, leading to inhibition of its inflammatory cascade
Cowin et al., Wound Repair Regen 2006 (Chronic Disease...) : Therefore, the aim of this study was to determine whether Etanercept could inhibit TNF-alpha activity in chronic wound fluid ... The effect of Etanercept on TNF-alpha activity was evaluated using both a TNF-alpha bioassay and an enzyme linked immunoassay
Wang et al., Gastroenterology 2006 (Intestinal Diseases) : Transgenic TNFR2 , but not TNFR1, expression allowed IFN-gamma independent TNF responses
Yang et al., Zhonghua Yi Xue Za Zhi 2006 (Spondylitis, Ankylosing) : Infliximab and Etanercept , 2 anti-TNF-alpha inhibitors , not only significantly decrease the ESR and CRP, but also decrease the serum level of MMP-3 of patients with AS
Lories et al., Arthritis Rheum 2007 (Ankylosis...) : Etanercept inhibited mouse TNFalpha in vitro and in vivo
Moghaddami et al., Arthritis Rheum 2007 : Modulation of TNF receptors (TNFRs) may contribute to the regulation of tissue damage, and n-6 polyunsaturated fatty acids ( PUFAs ) such as arachidonic acid ( AA ) can increase the expression of TNFRI and TNFRII on neutrophils
Bell et al., J Leukoc Biol 2007 (Inflammation) : We report ablated, soluble TNF-alpha, TNFRI, and TNFRII production by neutrophils and macrophages stimulated with various microbial antigens and greatly reduced TNF-alpha levels in vivo following inflammation induction
Yan et al., Cell Mol Neurobiol 2008 (Encephalitis) : RT-PCR analysis revealed that TNFR1 and TNFR2 were present in normal untreated type-2 astrocytes, and that TNF-alpha , TNFR1 and TNFR2 increased in type-2 astrocytes after exposure to TNF-alpha or LPS
Rossol et al., J Immunol 2007 : Several lines of evidence indicated that signaling through TNFR1/2 and through mTNF ( reverse signaling ) is involved in TNF-alpha production by monocytes after T cell contact : 1 ) blocking mTNF on activated T cells leads to a significant reduction in TNF-alpha production ; 2 ) down-regulation of TNFR1/2 on monocytes by transfection with small interfering RNA results in diminished TNF-alpha production ; 3 ) blocking or down regulating TNFR2 on activated T cells inhibits TNF-alpha production, indicating that mTNF on the monocyte surface mediates signaling ; 4 ) ligation of mTNF on monocytes by surface TNFR2 transfected into resting T cells induces TNF-alpha production due to reverse signaling by mTNF ; and 5 ) ligation of mTNF on monocytes by a soluble TNFR2 : Ig receptor construct induces TNF-alpha production due to reverse signaling
Yan et al., Brain Res 2007 : RT-PCR analysis revealed that TNFR1 and TNFR2 were present in normal untreated type-2 astrocytes and that TNF-alpha , TNFR1 and TNFR2 increased in type-2 astrocytes after exposure to TNF-alpha or LPS
Griffin et al., Journal of neuroinflammation 2008 (Alzheimer Disease) : Toward such manipulation in Alzheimer 's disease, a six-month study was conducted with 15 probable-Alzheimer patients who were treated weekly with perispinal injection of Etanercept , an FDA approved TNF inhibitor that is now widely used for treatment of rheumatoid arthritis and other systemic diseases associated with inflammation
Qin et al., Neurochem Res 2008 : We show here that cultured SCs express both TNFR1 and TNFR2 , and that activation of these receptors by TNF-alpha promotes expression of TNF-alpha
Ahn et al., Life Sci 2008 : In addition, EGCG attenuated TNFalpha mediated down-regulation of TNFalpha receptor 1 (TNFR1), but not TNFR2
Figiel et al., Acta Neurobiol Exp (Wars) 2008 : Different hypotheses pertain to the molecular and cellular effectors triggered by the activation of TNF receptors ( TNFRI and TNFR2 )
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : IFN-gamma and TNF-alpha up-regulated TNFR1, TNFR2 , Fas and membrane FasL on SMC
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2) , IL-1alpha, IL-1beta, IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
Misaki et al., Am J Pathol 2009 (Kidney Diseases...) : Since TRADD is not incorporated into TNFR2 mediated TNFalpha signaling, the persistent decrease in TRADD, associated with a mild decrease in TNFR1 levels, may function, at least in part, to divert TNFalpha signals toward a TNFR2 mediated pathway in UUO kidneys
Akilov et al., Exp Dermatol 2012 (Sezary Syndrome) : CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of TNFR1, TNFR2 , IER3 expression, and ROS production in response to TNF-a at an apoptotic dose
Roh et al., PloS one 2012 (Disease Models, Animal...) : Etanercept , a widely used inhibitor of tumor necrosis factor-a (TNF-a) , prevents retinal ganglion cell loss in a rat model of glaucoma ... Despite persistent elevation of IOP, Etanercept reduced microglial activation, TNF-a levels, axon degeneration in the optic nerve, and the loss of RGCs
Yang et al., Cancer Res 2012 : Together, our results define a pathway for macrophage induced bystander effects in which TNF-a triggers TNFRSF1b receptor signaling leading to increased production of Netrin-1, crypt hyperplasia, and decreased epithelial cell apoptosis
Lai et al., Horm Metab Res 2013 (Fatty Liver) : Etanercept could block TNF-a receptors to restore PPAR-d and improve renal function in mice with hepatic steatosis
Chopra et al., Carcinogenesis 2013 (Lung Neoplasms...) : We propose a novel mechanism in which TNF activates TNFR2 on Treg cells and thereby expands this immunosuppressive immune cell population
Wu et al., Pancreas 2013 : Etanercept blocks tumor necrosis factor a (TNF-a) , a proinflammatory cytokine that plays a role in cancer related cachexia and tumor growth
Chio et al., BMC neuroscience 2013 (Brain Injuries...) : Etanercept ( a TNF-a antagonist with anti-inflammatory effects ) attenuates TBI in rats by reducing both microglial and astrocytic activation and increased serum levels of TNF-a
Wortzman et al., PloS one 2013 : Comparison of TNF levels on the TNFR2 positive and negative T cells is consistent with TNF/TNFR2 interactions inducing feedback downregulation of TNF production by T cells, with greater effects in the lung compared to spleen
Wong et al., Biochim Biophys Acta 1995 : TNF-R1 but not TNF-R2 is responsible for TNF and LT 's induction of MnSOD
Manthey et al., Infect Immun 1993 : Herein, we examined the ability of these structures to regulate murine macrophage tumor necrosis factor (TNF) secretion and LPS-inducible gene expression ( tumor necrosis factor alpha [TNF-alpha ], interleukin-1 beta [IL-1 beta ], IP-10, type 2 TNF receptor [TNFR-2 ], D3, and D8 genes )
Douvdevani et al., Kidney Int 1996 : Down-regulation and shedding of TNF-R1 induced by IL-1, and the transient expression of TNF-R2 induced by IL-1 and TNF , may regulate the responses to TNF by HPMC
Huang et al., Life Sci 1998 (Brain Neoplasms...) : Selective induction of tumor necrosis factor receptor type II gene expression by tumor necrosis factor-alpha in C6 glioma cells ... The induction of TNF-R2 gene expression by TNF-alpha was dose dependent and seemed to be unique to TNF-alpha, as IL-6 had no effect