Gene interactions and pathways from curated databases and text-mining

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IL5 — IL8

Text-mined interactions from Literome

Suchin et al., J Am Acad Dermatol 2001 (Eosinophilia...) : Increased interleukin 5 production in eosinophilic Sézary syndrome : regulation by interferon alfa and interleukin 12
Lottaz et al., J Invest Dermatol 2001 : We hypothesize that inhibition of this pathway prevents secretion of interleukin-1, thereby downregulating interleukin-1 dependent autocrine induction of interleukin-8
Prause et al., Eur J Pharmacol 2003 : Pharmacological modulation of interleukin-17 induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells ... We found that interleukin-17 ( 1-1000 ng/ml ) increased the release of GCP-2, GRO-alpha and interleukin-8 in a concentration dependent manner
Waehre et al., J Am Coll Cardiol 2003 (Coronary Artery Disease) : Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy reduced the spontaneous release of IL-8 and MIP-1alpha from PBMCs in CAD patients
Vittori et al., J Allergy Clin Immunol 1992 : Protective effect of nedocromil sodium on the interleukin-1 induced production of interleukin-8 in human bronchial epithelial cells
Uchiyama et al., Am J Obstet Gynecol 1992 : These results indicate that interleukin-8-like chemotactic factor participates in the cervical ripening at term pregnancy and that the production of this factor is controlled effectively by interleukin-1
Warringa et al., Am J Respir Cell Mol Biol 1992 (Asthma) : We have investigated the modulatory role of IL-5 on N-formyl-methionyl-leucyl-phenylalanine ( FMLP ), neutrophil activating factor ( NAF/IL-8 ), platelet factor 4 (PF4), and cytokine induced chemotaxis of eosinophils from normal individuals
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Wuyts et al., J Heart Lung Transplant 2004 : N-acetylcysteine inhibits interleukin-17 induced interleukin-8 production from human airway smooth muscle cells : a possible role for anti-oxidative treatment in chronic lung rejection ?
Hirota et al., Rheumatol Int 1992 : Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha, TNF-beta, IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Darbonne et al., J Clin Invest 1991 : Their binding of IL-8 is rapidly reversible and does not result in receptor internalization, although bound IL-8 is resistant to extraction by pH 3 buffer at 5 degrees C. 125I-IL-8 binding to red cells was not inhibited by epidermal growth factor or interleukin 1, but was inhibited by monocyte chemotactic peptide-1, which is not a neutrophil chemotaxin, but is a member of the same family of polypeptides as IL-8
Larsen et al., Biochem Biophys Res Commun 1991 : 1,25 ( OH ) 2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production
Hua et al., Molecular oral microbiology 2010 (Periodontal Diseases) : Furthermore, as little as 2 µg ml(-1) mPE was sufficient to inhibit interleukin-1ß induced secretion of interleukin-8 in both gingival epithelial cells and THP-1 cells
Vindeløv et al., Growth Horm IGF Res 2011 (Adenoma...) : Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1ß and inhibited by growth hormone releasing hormone and somatostatin
Strieter et al., Am J Respir Cell Mol Biol 1990 : The induction of AMO derived IL-8 by tumor necrosis factor (TNF), lipopolysaccharide (LPS), and interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent
Swain et al., Proc Natl Acad Sci U S A 1981 : We conclude that the C.C3.11.75 TRF activity is not due to interleukin 1 or to interleukin 2 but to a third factor provisionally designated as ( DL ) TRF
Zaitseva et al., Infect Immun 1995 : Gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-5 induction was assayed by mRNA-specific PCR and by enzyme linked immunosorbent assay and bioassay for protein production
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Nakajima et al., J Immunol 1996 : Release of IL-8 protein and storage of IL-4 and IL-10 proteins were enhanced by exogenous IL-5 and inhibited by a transcription inhibitor, actinomycin D. Degranulation of stored granule proteins was not affected by actinomycin D
Hedges et al., Cytokine 1996 : IL-5 , IL-12, IL-13 and TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not affect IL-8 secretion
Miyamasu et al., Allergy 1997 : Because eosinophilopoietic factors are known to stimulate various functions of eosinophils, we examined the effect of interleukin (IL)-5 on chemoattractant induced IL-8 generation from eosinophils ... Although IL-5 alone induced little or no IL-8 production from eosinophils, short-term preincubation with IL-5 markedly enhanced the eosinophil IL-8 generation caused by C5a plus cytochalasin B ( CB )
Rudack et al., Laryngorhinootologie 1998 (Chronic Disease...) : These findings suggest that IL-8 plays a pivotal role in neutrophil dominated and IL-5 in eosinophil dominated sinusitis
Krakauer et al., J Infect Dis 1998 : Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and independent of interleukin-1 and tumor necrosis factor-alpha