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NOTCH1 — RUNX2

Text-mined interactions from Literome

Zayzafoon et al., J Biol Chem 2004 (Bone Neoplasms...) : Finally, we show that Notch and ERK activation are essential for Runx2 DNA binding activity and osteocalcin gene expression in C4-2B cells in response to osteogenic induction
Garg et al., Nature 2005 (Calcinosis...) : Consistent with the valve calcification phenotype, Notch1 transcripts were most abundant in the developing aortic valve of mice, and Notch1 repressed the activity of Runx2 , a central transcriptional regulator of osteoblast cell fate ... Consistent with the valve calcification phenotype, Notch1 transcripts were most abundant in the developing aortic valve of mice, and Notch1 repressed the activity of Runx2 , a central transcriptional regulator of osteoblast cell fate
Garg et al., Curr Opin Cardiol 2006 (Aortic Valve Stenosis...) : The NOTCH signaling pathway was linked to a molecular pathway for aortic valve calcification, as NOTCH1 was found to repress activation of Runx2 - a transcription factor critical for osteoblast cell fate that is up-regulated in calcified human aortic valves
Ann et al., J Bone Miner Res 2011 : Accumulated Runx2 suppressed Notch1 transcriptional activity by dissociating the Notch1-IC-RBP-Jk complex
Giambra et al., Nat Med 2012 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : We also show that PKC-? is regulated by a new pathway in which NOTCH1 induces runt related transcription factor 3 ( RUNX3 ), RUNX3 represses RUNX1 and RUNX1 induces PKC-?
Watanabe et al., PLoS Genet 2013 : Moreover, inhibition of Notch signaling did not affect the action of MAML1 on Runx2 , suggesting that the activation of Runx2 by MAML1 may be caused in a Notch independent manner