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EHMT1 — IGF1

Text-mined interactions from Literome

Dubé et al., Gastroenterology 2006 (Disease Models, Animal) : GLP-2 increased IGF-1 messenger RNA expression and IGF-1 secretion in intestinal cultures and increased expression of IGF-1 messenger RNA in mouse small intestine in vivo ... GLP-2 enhances intestinal IGF-1 expression and secretion, and IGF-1 is required for small and large intestinal growth in response to GLP-2
Nelson et al., Am J Physiol Regul Integr Comp Physiol 2008 (Body Weight) : Administration of an inhibitor of endogenous GLP-2 ( rat GLP-2 3-33 ) during ad libitum refeeding partially attenuated mucosal growth and prevented the increase in plasma IGF-I to fed levels ; however, plasma GLP-2 and jejunal IGF-I mRNA were restored to fed levels
Ivory et al., Am J Physiol Gastrointest Liver Physiol 2008 (Colitis...) : In colitis animals, intracellular cytokine analysis demonstrated that GLP-2 decreased lamina propria macrophage TNF-alpha production but increased IGF-1 production, whereas transforming growth factor-beta was unchanged
Velázquez et al., Mol Neurobiol 2009 : In addition, GLP-2R mRNA expression was increased by IGF-I , whilst mRNA expression of IGF-IR was higher in cells incubated with GLP-2 than in control cells
Leen et al., Endocrinology 2011 : Furthermore, GLP-2 increases IGF-I mRNA transcript levels in vitro in heterogeneous fetal rat intestinal cultures, as well as in vivo in the rodent small intestine ... Furthermore, pretreatment of ISEMF cells with the phosphatidylinositol 3 kinase (PI3K) inhibitors, LY294002 and wortmannin, abrogated the IGF-I mRNA response to GLP-2 , as did overexpression of kinase-dead Akt ... The role of PI3K/Akt in GLP-2 induced IGF-I mRNA levels in the murine jejunum was also confirmed in vivo