Chow et al., J Pharmacol Exp Ther 2011
:
To investigate whether the increased multidrug resistance protein 1 (Mdr1)/P-glycoprotein (P-gp) expression in the rat liver and kidney was caused by the VDR and not the FXR, we examined changes in Mdr1/P-gp expression in fxr ( +/+ ) and fxr ( -/- ) mice after intraperitoneal dosing of vehicle versus 1,25 ( OH ) ( 2 ) D ( 3 ) ( 0 or 2.5 µg/kg every other day for 8 days ) ... The observations suggest an important role of the VDR in the regulation of P-gp in the renal and brain disposition of P-gp substrates
Durk et al., J Neurochem 2012
:
Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat ( RBE4 ) and human ( hCMEC/D3 ) brain microvessel endothelial cell lines