◀ Back to VDR

RXRA — VDR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VDR → Complex of RXRA-VDR (directlyIncreases, RXRA/VDR Activity)
  Evidence: Expression of the platelet-derived growth factor-A subunit (PDGF-A) is regulated to a significant degree by DNA elements located in the 5'-distal region of the gene. A potent basal enhancer (ACE66) Electrophoretic mobility shift assays confirmed that the ACE66 sequence was recognized as a high affinity target for binding of heterodimers of recombinant vitamin D receptor (VDR) and its partner, retinoid-X receptor-alpha (RXRalpha)
• BioCarta control of gene expression by vitamin d receptor: NCOA62/TSC2/TRAP220 complex (SKIIP-TSC2-PPARBP) → RXR/VDR/WSTF/WINAC complex (RXRA-VDR-BAZ1B-SMARCE1-SMARCC2-SMARCC1-SMARCD1-ARID1A-SMARCA4-ACTL6A-TOP2B-CHAF1A-SUPT16H) (transcription, activates)
  
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: VDR/VDR/Vit D3 complex (VDR) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: VDR/VDR/Vit D3 complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: None → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RXRs (RXRB/RXRG/RXRB/RXRA) → VDR/VDR/DNA complex (VDR) (modification, collaborate) Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RXRs (RXRB/RXRG/RXRB/RXRA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs (RARA/RARG/RARB/RARB/RARB/RARG/RARB/RARA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: VDR/VDR/DNA complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: None → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs (RXRB/RXRG/RXRB/RXRA) → VDR/VDR/DNA complex (VDR) (modification, collaborate) Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs (RXRB/RXRG/RXRB/RXRA) → VDR/VDR/Vit D3 complex (VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs (RXRB/RXRG/RXRB/RXRA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: VDR/VDR/DNA complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: VDR/VDR/Vit D3 complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: VDR/Vit D3/DNA complex (VDR) → RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: VDR/Vit D3/DNA complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: None → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: VDR/Vit D3/DNA complex (VDR) → RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: VDR/Vit D3/DNA complex (VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: None → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Cheskis et al., Mol Cell Biol 1994
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: VDR — RXRA Pedigo et al., Oncogene 2005*
• IRef Bind_translation Interaction: VDR — RXRA (footprinting) Pedigo et al., Oncogene 2005*
• IRef Bind_translation Interaction: VDR — RXRA (electrophoretic mobility shift assay) Pedigo et al., Oncogene 2005*
• IRef Bind_translation Interaction: VDR — RXRA (two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Jiménez-Lara et al., J Biol Chem 1999*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Pedigo et al., Oncogene 2005*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Herdick et al., J Mol Biol 2000*
• IRef Biogrid Interaction: VDR — RXRA (colocalization, imaging technique) Seuter et al., Biochim Biophys Acta 2007*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Seuter et al., Biochim Biophys Acta 2007*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Hsieh et al., J Biol Chem 2003*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Sorg et al., Biochim Biophys Acta 2006*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Zhang et al., J Biol Chem 2001*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, two hybrid) Baudino et al., J Biol Chem 1998*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Baudino et al., J Biol Chem 1998*
• IRef Biogrid Interaction: VDR — RXRA (physical association, affinity chromatography technology) Song et al., Mol Endocrinol 2006*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Rachez et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Liu et al., Mol Endocrinol 2000*
• IRef Biogrid Interaction: VDR — RXRA (colocalization, imaging technique) Kim et al., J Bone Miner Res 2005*
• IRef Biogrid Interaction: VDR — RXRA (colocalization, imaging technique) Dunlop et al., J Mol Biol 2005*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Ting et al., Endocrine 2005*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Solomon et al., J Bone Miner Res 2001*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Carvallo et al., J Cell Physiol 2008*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, two hybrid) Yanagisawa et al., Science 1999
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Ismail et al., Mol Endocrinol 2004*
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Yanagisawa et al., Science 1999
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: VDR — RXRA (direct interaction, pull down) Peleg et al., J Cell Biochem 2010*
• IRef Dip Interaction: Complex of VDR-VDR-RXRA-RXRA-MED1-MED1 (physical association, cosedimentation in solution) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: Complex of VDR-VDR-RXRA-RXRA-NCOA1-NCOA1 (physical association, molecular sieving) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: VDR — RXRA (direct interaction, molecular sieving) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: VDR — RXRA (direct interaction, pull down) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: VDR — RXRA (direct interaction, cosedimentation in solution) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: VDR — RXRA (direct interaction, x ray scattering) Rochel et al., Nature structural & molecular biology 2011*
• IRef Hprd Interaction: Complex of 16 proteins (in vivo) Zhang et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of RXRA-NCOA1-VDR-VDR-NCOA1-RXRA-NCOA1-VDR-RXRA (in vivo) Zhang et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Zhang et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Zhang et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of SNW1-VDR-RXRA-VDR-RXRA-SNW1-SNW1-VDR-RXRA (in vivo) Zhang et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Koszewski et al., J Steroid Biochem Mol Biol 2003*
• IRef Hprd Interaction: VDR — RXRA (in vitro) Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
• IRef Hprd Interaction: VDR — RXRA (in vivo) Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
• IRef Hprd Interaction: VDR — RXRA (two hybrid) Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: VDR — RXRA (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: VDR — RXRA (direct interaction, electron microscopy) Orlov et al., EMBO J 2012*
• IRef Ophid Interaction: VDR — RXRA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Segaert et al., J Invest Dermatol 2000 : Suppression of vitamin D receptor and induction of retinoid X receptor alpha expression during squamous differentiation of cultured keratinocytes ... Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited vitamin D receptor expression but only interferon-gamma induced retinoid X receptor alpha
Jääskeläinen et al., Eur J Biochem 1995 : We have studied the role of retinoid X receptor alpha (RXR alpha) in vitamin D receptor (VDR) responsive interactions using nuclear extracts from human osteoblast-like MG-63 osteosarcoma cells and its specific response element from human osteocalcin gene ( OC-VDRE )