Kang et al., EMBO J 2005
:
Accordingly, HDAC4 or 5 is required for efficient TGF-beta mediated inhibition of Runx2 function and is involved in osteoblast differentiation
Schroeder et al., J Bone Miner Res 2005
:
These studies show that histone deacetylase activity regulates osteoblast differentiation and bone formation at least in part by enhancing Runx2 dependent transcriptional activation
Saito et al., Osteoarthritis Cartilage 2013
(MAP Kinase Signaling System) :
HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2 , ADAMTS-5, and MMP-3 at both the mRNA and protein levels within 1h ... The CTS induced expression of RUNX-2 and ADAMTS-5 was suppressed by HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes