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CRK — HGF

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CRK (CRK) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF) → HGF(dimer)/MET(dimer)/GAB1/CRK complex (MET-GAB1-CRK-HGF) (modification, collaborate)
  Lamorte et al., Oncogene 2000, Lamorte et al., J Biol Chem 2002*, Chan et al., Oncogene 2010
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Crk/p130 Cas complex (BCAR1-CRK) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Garcia-Guzman et al., Oncogene 1999*, Riordan et al., Biochem J 2000*, Lamorte et al., Oncogene 2000
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF(dimer)/MET(dimer) complex (MET-HGF) → CRK (CRK) (modification, activates) Garcia-Guzman et al., Oncogene 1999*, Riordan et al., Biochem J 2000*, Lamorte et al., Oncogene 2000
  Evidence: physical interaction

Text-mined interactions from Literome

Kobayashi et al., Kidney Int 2003 : Moreover, stimulation of the cells with HGF resulted in a marked increase ( five- to tenfold ) in phosphorylation of extracellular signal related protein kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( MAPK ), but not of c-Jun NH2 terminal kinase (JNK)
Coltella et al., Int J Cancer 2006 (Adenocarcinoma...) : In fact, p38 MAPK activity is stimulated by HGF and further increased by the combined treatment with HGF and either CDDP or PTX
Olivero et al., Mol Cancer Ther 2006 (Ovarian Neoplasms) : We showed recently that hepatocyte growth factor (HGF) enhances death of human ovarian cancer cell lines treated with cisplatin ( CDDP ) and that this effect is mediated by the p38 mitogen activated protein kinase
Watanabe et al., Mol Cancer Res 2006 (Sarcoma, Synovial) : HGF stimulation induced the sustained phosphorylation on Y307 of Gab1 where Crk was recruited
Matsushita et al., Cancer Res 2007 (Neoplasm Invasiveness...) : HGF actions on c-Met tyrosine phosphorylation and p38 mitogen activated protein kinase ( MAPK ) activation were increased in Np-1 overexpressing COLO-357 cells by comparison with HGF effects in sham transfected cells
Makondo et al., Eur J Pharmacol 2008 : In addition, geldanamycin treatment did not enhance the HGF induced phosphorylation of Akt, ERK1/2 and p38MAPK
Uruno et al., Hypertens Res 2008 : Our data therefore indicate that the stimulatory effects of low-dose fluvastatin on the HGF induced angiogenesis are mediated by its inhibitory effects on p38 MAPK phosphorylation induced by HGF , which may result in the suppression of EC apoptosis
Brusevold et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In the E10 cell line, EGF and HGF induced phosphorylation of EGF receptor (EGFR) and Met, respectively, phosphorylation of ERK1/2, p38 and Akt, and dose dependent activation of cell migration