Gene interactions and pathways from curated databases and text-mining

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CCND1 — SHH

Text-mined interactions from Literome

Hartmann et al., Am J Pathol 2005 (Cerebellar Neoplasms...) : In GCPs, a synergistic effect of Shh and Igf-II on proliferation and gli1 and cyclin D1 mRNA expression was found
Vaillant et al., Development 2007 : The binding of PN-1 to LRPs interferes with SHH induced cyclin D1 expression
Dormoy et al., Molecular cancer 2009 (Carcinoma, Renal Cell...) : Gli1, cyclin D1 , Pax2, Lim1, VEGF, and TGF-beta were exclusively expressed in tumors and were shown to be regulated by SHH , as evidenced by immunoblot after SHH inhibition
Li et al., Arterioscler Thromb Vasc Biol 2010 (Disease Models, Animal...) : Inhibition of Shh signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G ( 1 ) arrest and reduced cyclin D1 , cyclin E, and phosphorylated retinoblastoma (pRB) levels