Gene interactions and pathways from curated databases and text-mining

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COMT — MAOB

Text-mined interactions from Literome

Stocchi et al., Mov Disord 2008 (Movement Disorders...) : Medical management includes manipulation of levodopa dosing to establish the optimum treatment schedule, improving levodopa absorption, catechol-O-methyl transferase-inhibition ( COMT ), Monoamine oxidase-B (MAO-B) inhibition , dopaminergic agonists, amantadine, and continuous dopaminergic infusions
Pahwa et al., Curr Med Res Opin 2009 (Disease Progression...) : A number of therapeutic options are available to optimize therapeutic outcome, including modification of the levodopa dose or dosing schedule, switching to another levodopa formulation and the use of adjunct therapies, such as catechol-O-methyl transferase inhibitors, dopamine agonists and monoamine oxidase-B inhibitors