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EPHB2 — IL13
Text-mined interactions from Literome
Valledor et al., J Biol Chem 2000
:
Granulocyte/macrophage colony stimulating factor,
interleukin 3, and TPA, all of which induced macrophage proliferation, also
induced ERK activity, which was maximal at 5 min poststimulation
Hirst et al., Am J Respir Crit Care Med 2002
:
Activation of IL-4Ralpha by
IL-13 or IL-4
induced signal transducer and activation of transcription-6 ( STAT6 ), p42/ p44
ERK , p38, and to a lesser extent, SAPK/JNK mitogen activated protein kinase phosphorylation
Maggi et al., J Biol Chem 2003
(Cardiovirus Infections...) :
ERK activation is
required for double stranded RNA- and virus induced
interleukin-1 expression by macrophages
MacGillivray et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
The protein tyrosine phosphatase SHP-2 regulates
interleukin-1 induced
ERK activation in fibroblasts
Chang et al., J Biol Chem 2004
(Inflammation...) :
The induction of prostaglandin E2 production,
interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially
regulated by
MEK/ERK activation
Wang et al., J Biol Chem 2005
:
SHP-2 modulates
interleukin-1 induced Ca2+ flux and
ERK activation via phosphorylation of phospholipase Cgamma1
Miranda et al., Leuk Res 2005
(MAP Kinase Signaling System) :
Additionally,
interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also
inhibited the ability of G-CSF to stimulate prolonged
MEK/ERK activation
Lee et al., J Clin Invest 2006
(Inflammation) :
We found that Tg
IL-13 expression in the lung
led to potent activation of
ERK1/2 but not JNK1/2 or p38 ... Thus,
ERK1/2 is
activated by
IL-13 in the lung in a STAT6 independent manner where it contributes to IL-13 induced inflammation and remodeling and is required for optimal IL-13 stimulation of specific chemokines and proteases as well as the inhibition of specific antiproteases
Zhou et al., J Allergy Clin Immunol 2007
(Asthma...) :
ERK phosphorylation was
increased by
IL-13 and IL-13+TGF-beta1 ... These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive effect of
IL-13 induced
ERK on Smad signaling
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Fujisawa et al., Respirology 2008
(Metaplasia) :
In contrast,
ERK1/2 was constantly activated and was not
enhanced by
IL-13
Wu et al., Arch Biochem Biophys 2009
(MAP Kinase Signaling System) :
The EGCG induced mRNA up-regulation of IL-2 and IL-5 was predominantly affected by the extracellular signal regulated protein kinase ( ERK ) signalling, whereas
IL-13 gene expression, the most responsive to the EGCG treatment, was
dependent on neither
ERK nor c-jun NH ( 2 ) -terminal kinase ( JNK ) signalling
Woolson et al., Cell Signal 2009
:
Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates
ERK1,2 activation in
response to either leptin or a soluble
interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009
:
Interleukin-10 production by Th1 cells requires
interleukin-12 induced STAT4 transcription factor and
ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009
(Inflammation...) :
Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha,
interleukin (IL)-6 , and IL-12 p40, and the
activation of
ERK1/2 and p38
Kono et al., Pulm Pharmacol Ther 2010
(Asthma) :
Furthermore, DMS inhibited
IL-13 induced
ERK1/2 phosphorylation but neither p38 MAPK nor STAT6 phosphorylation
Fujisawa et al., Int J Cancer 2012
(Neoplasm Invasiveness...) :
Mechanistically,
IL-13 enhanced
ERK1/2 , AP-1 and MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells
Lo et al., J Biol Chem 1998
:
Requirements of focal adhesions and calcium fluxes for
interleukin-1 induced
ERK kinase activation and c-fos expression in fibroblasts