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BCR — TERF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gold et al., Immunol Rev 2000
:
In this review, we discuss the
role of phosphatidylinositol 3-kinase (PI3K) and
Rap 1 in
B-cell receptor (BCR) signaling ... We showed that the
BCR activates
Rap1 via phospholipase C-dependent production of diacylglycerol
McLeod et al., Int Rev Immunol 2001
:
In this review, we summarize our recent work showing that the
B cell antigen receptor (BCR) , as well as chemokine receptors,
activate Rap1 via a pathway that involves phospholipase C-dependent production of diacylglycerol ( DAG ) ... The possible identities of the DAG regulated guanine nucleotide exchange factors ( GEFs ) and GTPase activating proteins ( GAPs ) that regulate the
activation of
Rap1 by the
BCR and chemokine receptors will be discussed
Mizuchi et al., Biochem Biophys Res Commun 2005
:
BCR/ABL activates
Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells ... Here we demonstrate that the inducible expression of
BCR/ABL in a murine hematopoietic cell line, TonB210,
leads to the activation of the Ras family small GTPase
Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Machtaler et al., J Cell Sci 2011
:
Expression of wild-type Cx43-GFP, but not Cx43dT-GFP, was sufficient to restore sustained,
BCR mediated
Rap1 activation and cell spreading
McLeod et al., J Biol Chem 1998
:
In this report, we show that
BCR engagement
activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ...
Activation of
Rap1 by the
BCR was greatly reduced in phospholipase C-gamma-deficient B cells, whereas both a synthetic DAG and phorbol dibutyrate could activate Rap1 in B cells ... However, the DAG dependent pathway by which the
BCR activates
Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the
BCR activates
Rap1 via a novel DAG dependent pathway