Gene interactions and pathways from curated databases and text-mining

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IL4 — NGF

Text-mined interactions from Literome

Gibbs et al., Int Immunopharmacol 2005 : Here, we compared the abilities of IL-3 and NGF to stimulate basophil histamine, IL-4 or IL-13 release, either directly or in conjunction with IgE dependent stimulation and assessed the intracellular signals responsible
Jelaso et al., Int J Dev Neurosci 2005 : In the mammalian nervous system, the cytokine, interleukin-1beta (IL-1beta) induces expression of NGF
von Boyen et al., J Neuroendocrinol 2006 (Inflammation) : NGF is continuously secreted from cultured EGCs and proinflammatory cytokines and lipopolysaccharides stimulate the secretion of this neurotrophin in a time- and dose- dependent manner, whereas interleukin-4 had no effect on NGF expression
Marianecci et al., J Control Release 2010 : The treatment of HLF cells with BDP loaded non-ionic surfactant vesicles determined a noticeable increase of the drug anti-inflammatory activity by reducing the secretion of both constitutive and interleukin-1ß stimulated nerve growth factor ( as inflammatory index ) of 68 % and 85 %, respectively
Varilek et al., Am J Physiol 1995 : Caco-2 monolayers primarily secreted NGF from the basolateral compartment, and interleukin-1 enhanced its secretion
Brodie et al., J Neuroimmunol 1994 : IL-4 also induced the secretion of nerve growth factor by these cells
Pshenichkin et al., J Neurochem 1994 : Transcriptional and posttranscriptional mechanisms involved in the interleukin-1 , steroid, and protein kinase C regulation of nerve growth factor in cortical astrocytes
Awatsuji et al., J Neurosci Res 1993 : IL-4 and IL-5 produced marked increases in NGF mRNA levels in astrocytes as demonstrated by the reverse transcription-polymerase chain reaction ( RT-PCR ) method ... The stimulatory effect of IL-4 and IL-5 on NGF synthesis was completely inhibited by the addition of anti-IL-4 monoclonal antibody and anti-IL-5 monoclonal antibody, respectively