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FGF2 — RHOA
Text-mined interactions from Literome
Harada et al., J Biol Chem 2005
:
Direct interaction of Rnd1 with FRS2 beta regulates Rnd1 induced down-regulation of
RhoA activity and is
involved in
fibroblast growth factor induced neurite outgrowth in PC12 cells
Vogt et al., Cell Signal 2007
:
The switch from Rac1 to
RhoA activation in H10 cells was
controlled by
fibroblast growth factor-2 (FGF-2) , lowering the expression of RGS3L
Jeon et al., J Cell Physiol 2010
:
Lysophosphatidic acid (LPA) treatment and the expression of constitutively active ( CA )
-RhoA ( RhoA V14 )
impaired neurite formation in response to
bFGF , while Tat-C3 exoenzyme and the expression of dominant negative ( DN ) -RhoA ( RhoA N19 ) stimulated neurite outgrowth ... GTP bound
RhoA levels were reduced in
response to
bFGF , which suggests that the inactivation of RhoA is essential to neurite outgrowth in response to bFGF
Kanazawa et al., PloS one 2010
(MAP Kinase Signaling System) :
bFGF activated
RhoA , Rac1, PI3-kinase, and JNK in cultured fibroblasts
Huang et al., Neurobiol Dis 2012
(Cerebral Hemorrhage, Traumatic) :
Exogenous
FGF2 increased activated FGFR, Akt, and Rac1 but
reduced activated
RhoA protein expression at 72 h after cICH ( p < 0.05, compared to vehicle ), which was reversed by FGFR and PI3K inhibition