van den Burg et al., Gen Comp Endocrinol 2005
:
The origin of this variable response was investigated by ( 1 ) studying the effects of corticotropin releasing hormone (CRH) on alpha-MSH and NAc beta-end release in vitro, ( 2 ) establishing where in the second messenger pathway coupled to CRH receptors melanotrope responsiveness is determined, and ( 3 ) testing modulatory actions of other hypothalamic factors ( here opioid beta-endorphin )
Yang et al., Immunol Lett 2005
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Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC) , which suggests that reactive oxygen intermediates ( ROI ) may be involved in regulating IL-18