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HDAC2 — OPN1LW
Text-mined interactions from Literome
Lu et al., J Biol Chem 2003
:
Although inhibition of
histone deacetylase activity
results in an increase of CREB- or
CBP mediated gene expression, mutation of all three putative acetylation sites in the CREB activation domain markedly enhances the ability of CREB to activate a cAMP-responsive element dependent reporter gene
Yun et al., J Nutr Biochem 2011
(Diabetes Mellitus, Type 2) :
Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated
CBP/p300 gene expression, and
induced HDAC2 expression by curcumin
Suzuki et al., J Biol Chem 2011
(Cell Transformation, Neoplastic...) :
Furthermore, the inhibition of MEK or
HDAC restored
Cbp expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation