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PLAU — STAT3

Text-mined interactions from Literome

Dumler et al., J Biol Chem 1999 : In this study, we demonstrate that Stat4 and Stat2, but not Stat3 , Stat5, or Stat6, are rapidly activated in response to uPA
Shetty et al., Am J Physiol Lung Cell Mol Physiol 2006 : uPA induced Stat3-DNA binding activity in a time dependent manner ... uPA induced Stat3 activation does not require uPA catalytic activity, as the uPA amino-terminal fragment alone was as potent as active two-chain uPA ( tcuPA ) in causing this effect ... Single-chain uPA likewise induced tyrosine phosphorylation of Stat3 to a similar extent as intact tcuPA ... Plasmin did not alter uPA induced Stat3 activation ... These results reveal for the first time that the uPA-uPAR interaction leads to activation of Stat3 , independent of its catalytic activity but dependent on its interaction with its receptor, uPAR, leading to DNA synthesis in lung epithelial cells