UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → 3BP2 (SH3BP2) (modification, collaborate) Deckert et al., Immunity 1998
Evidence: physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Deckert et al., Immunity 1998
Evidence: physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: 3BP2 (SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Deckert et al., Immunity 1998
Evidence: physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP1 (PTPN6) → TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) (modification, activates)
Yu et al., FEBS J 2006
Evidence: mutant phenotype
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → None (modification, activates) Deckert et al., Immunity 1998
Evidence: reporter gene