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FXR1 — IL6

Text-mined interactions from Literome

Jiang et al., Diabetes 2007 (Diabetic Nephropathies...) : In renal mesangial cells, overexpression of FXR or treatment with GW4064 also inhibited SREBP-1c and other lipogenic genes, transforming growth factor-beta, and interleukin-6 , suggesting a direct role of FXR in modulating renal lipid metabolism and modulation of fibrosis and inflammation
Mencarelli et al., Am J Physiol Heart Circ Physiol 2009 (Atherosclerosis...) : FXR activation by natural and synthetic ligands in these cell types attenuated IL-1beta, IL-6 , and TNF-alpha gene induction in response to Toll-like receptor 4 activation by LPS
Ogura et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2012 (Reperfusion Injury) : We also investigated the effect of IL-6 on FXR , PXR and CAR expression levels and their localization levels in nuclei in in vitro experiments ... FXR , PXR and CAR localization levels in nuclei were suppressed by 0.5-10 ng/mL, 10-100 ng/mL and 10-100 ng/mL IL-6 treatment for 24 h, respectively