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Zhang et al., J Cereb Blood Flow Metab 2009 (Disease Models, Animal...) : In addition, adjuvant treatment with atorvastatin at 4 h and with tPA at 6 h reduced tPA induced upregulation of protease activated receptor-1, intercellular adhesion molecule-1 , and matrix metalloproteinase-9, and concomitantly reduced cerebral microvascular platelet, neutrophil, and fibrin deposition compared with rats treated with tPA alone at 6 h
Labarrere et al., PloS one 2012 (Vascular Diseases) : In a prospective cohort study, we developed multivariate regression models evaluating markers of atherothrombosis ( fibrin, antithrombin and tissue plasminogen activator [tPA ] ) and endothelial activation ( intercellular adhesion molecule-1 ) in serial biopsies obtained during the first three months post-transplantation from 172 patients ( median follow-up = 6.3 years ; min = 0.37 years, max = 16.3 years )