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CD4 — IL9
Text-mined interactions from Literome
Pepe et al., Curr Pharm Des 2006
:
This Th1 polarizing activity is mediated by
interleukin-12 released by infected CDs in the
presence of
CD4 ( + ) cells
Ariga et al., Immunology 2007
:
Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive
CD4 ( + ) T cells
induces transient T-bet expression,
interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Staudt et al., Immunity 2010
(Asthma) :
Herein, we report that IRF4 is also crucial for the development and function of an interleukin-9 (IL-9) producing CD4 ( + ) T cell subset designated Th9. IRF4-deficient
CD4 ( + ) T cells failed to develop into IL-9 producing Th9 cells, and IRF4-specific siRNA
inhibited IL-9 production in wild-type CD4 ( + ) T cells
Vandergeeten et al., Blood 2013
(HIV Infections) :
When administered to HIV infected subjects receiving suppressive ART,
interleukin-7 (IL-7)
increases the number of
CD4 ( + ) T cells by promoting their survival and proliferation
Suzuki et al., J Virol 1999
:
Among them,
interleukin-12 (IL-12) and IL-4
induce naive
CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively