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IL8 — VEGFA

Text-mined interactions from Literome

Gloddek et al., J Endocrinol 1999 : Pituitary adenylate cyclase activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells
Vasse et al., Arterioscler Thromb Vasc Biol 1999 : OSM induced only a slight increase in the urokinase receptor and a 60 % increase in VEGF secretion, whereas it does not modify IL-8 secretion or bFGF levels
Tsuji et al., Biol Pharm Bull 2000 : Effects of sulfhydryl compounds on interleukin-1 induced vascular endothelial growth factor production in human synovial stromal cells
Tahara et al., Verh Dtsch Ges Pathol 2000 (Neoplasm Invasiveness...) : IL-8 increases the expression of EGF receptor, VEGF and IL-8 itself by tumor cells themselves, whereas IL-8 decreases expression of E-Cadherin, associated with increase in expression and activity of MMP-9 by tumor cells
Nör et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Transfection of antisense Bcl-2 into HDMECs blocked VEGF mediated induction of IL-8
Lee et al., J Biol Chem 2002 : Interestingly, we also observed that VEGF/VPF induced interleukin-8 (IL-8) expression in HBMECs and that IL-8 mRNA was maximal after 1 h of VEGF/VPF treatment of the cells ... Furthermore, addition of anti-IL-8 antibody blocked this increased migration, indicating that VEGF/VPF induced the functional expression of IL-8 protein in HBMECs ... Enzyme linked immunosorbent assay data and immunoprecipitation analysis revealed that although VEGF/VPF induced IL-8 expression at the translational level in HBMECs, basic fibroblast growth factor failed to induce this protein expression within 12 h. VEGF/VPF increased IL-8 production in HBMECs through activation of nuclear factor-KB via calcium and phosphatidylinositol 3-kinase pathways, whereas the ERK pathway was not involved in this process ... Taken together, these data demonstrate for the first time that VEGF/VPF induces IL-8 expression in HBMECs and contributes to leukocyte infiltration through the expression of chemokines, such as IL-8, in endothelial cells
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 also induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Yokoyama et al., Oral Microbiol Immunol 2005 : Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose dependent manner
Wang et al., Cell Signal 2005 (MAP Kinase Signaling System...) : Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Rodriguez et al., Int J Cancer 2006 (Neoplasms...) : VEGF induced IL-8 production at the mRNA ( real time RT-PCR ) and protein levels ( ELISA ) are also suppressed with EGCG
Charalambous et al., Cancer Res 2005 (Brain Neoplasms...) : Treatment with antibody against vascular endothelial growth factor ( VEGF ) shows that production of IL-8 by TuBECs is dependent on VEGF ... In summary, these studies show that TuBECs constitutively secrete IL-8 and autocrine activation by IL-8 is the result of VEGF stimulation
Liu et al., Biochem Biophys Res Commun 2006 (Prostatic Neoplasms) : Thrombin induced the expression and secretion of IL-8 and VEGF , with more pronounced effects on IL-8
Ryzhov et al., J Pharmacol Exp Ther 2007 (Anoxia...) : Thus, adenosine receptors act in a cooperative fashion with hypoxia to stimulate VEGF and induce IL-8 secretion not stimulated by hypoxia alone
Yao et al., Zhonghua Yi Xue Za Zhi 2007 (Glioma) : The mRNA expression of VEGF and mRNA expression of IL-8 in the U87 cells activated by fMLF were significantly higher than those of the control group ( both P < 0.05 ), and Nordy significantly attenuated the mRNA expression of VEGF and IL-8 at different time points ( all P < 0.05 )
Yao et al., J Neurooncol 2008 (Disease Models, Animal...) : In this study, we examined the capacity of FPR to regulate the production of another angiogenic factor, the chemokine IL-8 ( CXCL8 ), in addition to its demonstrated ability to induce VEGF secretion by malignant glioma cells
Li et al., Cancer Sci 2008 (Neovascularization, Pathologic...) : Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer ... Exogenous IL-8 up-regulated the expression of vascular endothelial growth factor ( 165 ), and neuropilin (NRP)-2 in BxPC-3 cells, one of human pancreatic cancer cell lines
Chen et al., Endocrinology 2008 : LPA enhanced IL-8 expression in a dose- and time dependent manner, whereas vascular endothelial growth factor or IL-6 expression was not affected by LPA treatment
Martin et al., J Biol Chem 2009 : CXCL8/IL8 stimulates vascular endothelial growth factor ( VEGF ) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM ( Carma3/Bcl10/Malt1 ) complex ... Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the CXCL8/IL8 induced NFkappaB activation and VEGF up-regulation ... Together, these findings support the existence of an NFkappaB mediated pathway by which the proinflammatory chemokine CXCL8/IL8 controls the expression of VEGF in endothelial cells, thereby promoting the activation of VEGF receptors in an autocrine fashion
Hao et al., Am J Physiol Cell Physiol 2009 : Importantly, the VEGF induced production of IL-6, IL-8 , and GRO-alpha was inhibited approximately 70 %, 40 %, or 37 % by PKD1 silencing ( more than 90 % knockdown ) with three small interference RNAs that target different PKD1 regions ... Our results indicate that VEGF , via VEGFR2-PKD1 axis, induces the production of proinflammatory cytokine IL-6, IL-8 , and GRO-alpha in ECs but not in leukocytes, which may offer new insights into the mechanism of the proinflammatory activity of VEGF
Hanrahan et al., J Clin Oncol 2010 (Lung Neoplasms) : For example, increases in IL-8 with VCP, MMP-9 with CP, and VEGF with vandetanib monotherapy were associated with increased progression risk, and increase in intercellular adhesion molecule 1 with vandetanib was associated with decreased risk
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Murayama et al., Cell Biol Int 2010 : Effect of VEGF ( vascular endothelial growth factor ) on expression of IL-8 ( interleukin-8 ), IL-1beta and their receptors in bovine theca cells ... Secondly, we examined the effects of VEGF on the expression of IL-8 , IL-1beta and their receptors genes in cultured bovine theca cells ... VEGF stimulates the expression of IL-8 and CXCR1 mRNA ... Our data demonstrate that VEGF stimulated the expression of the IL-8 and CXCR1 genes and that CXCR2 expression was suppressed by VEGF , suggesting a follicle stage dependent expression pattern for the IL-8 system
Westra et al., BMC musculoskeletal disorders 2010 (Arthritis...) : THP-1 and SF macrophages produced high levels of VEGF, IL-8 , and MMP-9, and VEGF protein production was significantly inhibited by PI3K-inhibitor, and by both CaMKII inhibitors
Lee et al., Inflammation 2011 (Breast Neoplasms...) : Expression of interleukin (IL)-6, IL-8 , and tumor necrosis factor-a were substantially increased and involved in macrophage induced VEGF and MMP-9 mRNA expression in MCF-7 cells
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : Tacrolimus ( FK506 ) inhibits interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Kaga et al., Vascul Pharmacol 2012 (Inflammation) : In addition, bFGF, but not HGF or VEGF , significantly activated an essential transcription factor for inflammation, NF?B, and gene expression of its downstream inflammation related cytokines ( IL-8 and MCP-1 ) in VSMCs, accompanied by an increase in the vascular permeability in the rat paper disc model
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8 , MMP2 and 9 expressions in RA synovial explants
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 : a potential mechanism for inflammatory angiogenesis
Kvanta et al., Curr Eye Res 1995 : Both interleukin-1 and transforming growth factor beta induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with interleukin-1 induced VEGF protein expression in choroidal fibroblasts but not in RPE cells
Yoshida et al., Mol Cell Biol 1997 : Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha dependent IL-8 production and partially abrogated TNF-alpha dependent VEGF production, and an Sp1 antisense sequence partially inhibited TNF-alpha dependent production of VEGF