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TNF — TXN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
TRX/ASK1 complex (MAP3K5-TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
thioredoxin (TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Hashimoto et al., Biochem Biophys Res Commun 1999
:
The results showed that
TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production by
TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 )
Maurice et al., Arthritis Rheum 1999
(Arthritis, Rheumatoid) :
The
effect of oxidative stress and
tumor necrosis factor alpha (TNF alpha) on
TRX expression by cultured rheumatoid fibroblast-like synoviocytes was studied ... Stimulation of synovial fibroblast-like synoviocytes with either H2O2 or
TNF alpha induced an increase in the production of
TRX
Barral et al., Melanoma Res 2000
(Lymphatic Metastasis...) :
Secondly, we analysed whether redox stimulation by
Trx alone or in combination with the phorbol ester PMA
affected the expression and release of
TNFalpha
Takeuchi et al., Antioxid Redox Signal 2000
:
Thioredoxin inhibits
tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Yamawaki et al., J Clin Invest 2005
(Inflammation) :
In cultured ECs, reduction of TXNIP expression by small interfering RNA increased
TRX binding to ASK1 and
inhibited TNF activation of JNK/p38 and VCAM1 expression
Kitaoka et al., Endocrinology 2011
(Nerve Degeneration...) :
17ß-E2 treatment also totally abolished
TNF induced decreases in
Trx1 protein levels in isolated RGC and the optic nerve