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NOS2 — PLA2G1B

Text-mined interactions from Literome

Park et al., J Immunol 2003 : Group IIA PLA(2) stimulated iNOS expression and promoted nitrite production in a dose- and time dependent manner in Raw264.7 cells ... Pretreatment with LY294002, a PI3K inhibitor, strongly suppressed group IIA PLA(2) induced iNOS expression and PI3K/Akt activation ... The promoter activity of iNOS was stimulated by group IIA PLA(2) , and this was suppressed by LY294002 ... Transfection with Akt cDNA resulted in Akt protein overexpression in Raw264.7 cells and effectively enhanced the group IIA PLA(2) induced reporter activity of the iNOS promoter
LaPointe et al., Hypertension 1998 : Since NO has been shown to directly stimulate COX activity and the resulting prostanoids to modulate IL induction of iNOS, we questioned whether PLA2 and/or COX products are involved in IL regulation of iNOS and NO production in NVM ... Pretreatment with ONO blocked IL-stimulated NO production and iNOS protein, suggesting that PLA2 products are involved in regulation of iNOS synthesis