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GPI — PTGS2

Text-mined interactions from Literome

Tegeder et al., J Pharmacol Exp Ther 2000 : Because PGF ( 1alpha ) is the stable breakdown product of PGI ( 2 ), these results suggest that COX-2 contributes to PGI ( 2 ) synthesis in the rat stomach
Smith et al., Arterioscler Thromb Vasc Biol 2002 : However, selective inhibition of COX-2 , but not COX-1, blocked PGI2 production under low cholesterol conditions
Jaffar et al., J Immunol 2002 (Inflammation) : Selective inhibition of cyclooxygenase-2 in vivo specifically reduced PGI ( 2 ) synthesis and resulted in a marked increase in Th2 mediated, but not Th1 mediated, lung inflammation
Pirkebner et al., J Cell Physiol 2004 (Colonic Neoplasms) : Additionally, analysis utilizing protein synthesis inhibitor cycloheximide demonstrated that pHi mediated inhibition of COX-2 mRNA expression requires de novo protein synthesis of regulatory protein ( s )
Shinmura et al., Basic Res Cardiol 2004 (Myocardial Reperfusion Injury) : A COX-2 dependent increase in PGI ( 2 ) production is essential for BW373U86 induced late PC in both sexes and in both young and old rats
Schildknecht et al., FASEB J 2004 : Specific COX-2 inhibitors completely blocked PGI2 formation but PGE2 synthesis only partially
Norata et al., Int J Mol Med 2004 : N-LDL and Ox-LDL increased PGE2 release in a Cox-2 dependent manner while TXA2 and PGI2 release were not affected either by n-LDL or Ox-LDL
Hui et al., Prostaglandins Leukot Essent Fatty Acids 2004 (Liver Neoplasms) : COX-2 was responsible for the production of PGE ( 2 ) and PGI ( 2 ) in PDGF stimulated LI90 cells
Huang et al., Hum Reprod 2004 : The effects of COX-2 inhibitor on PGI2 production were ascertained ... The PGI2 production was markedly reduced by a selective COX-2 inhibitor
Damirin et al., Mol Pharmacol 2005 : In conclusion, S1P induced cAMP accumulation through S1P receptors, including S1P(2) receptor and G ( i/o ) protein mediated stimulation of intracellular signaling pathways involving cyclooxygenase-2 dependent PGI ( 2 ) synthesis
Smith et al., J Lipid Res 2005 : We previously demonstrated that cholesterol deprivation increases endothelial cyclooxygenase-2 (COX-2) dependent prostacyclin [ prostaglandin I2 (PGI2) ] production in vitro
Fauti et al., FEBS J 2006 : In agreement with this conclusion, the overexpression of ectopic Cox-2 and PGI2 synthase (PGIS) resulted in massive PGI2 synthesis but did not activate the transcriptional activity of PPARbeta
Pham et al., J Cell Biochem 2006 : Recently, we showed in an ileal epithelial cell line ( IEC-18 ), angiotensin II-induced COX-2 dependent PGI2 production through p38MAPK, and calcium mobilization ( J. Biol. Chem. 280 : 1582-1593, 2005 )
Cook-Johnson et al., Biochim Biophys Acta 2006 : PGI ( 2 ), but not TXA ( 2 ) synthesis, was absolutely dependent on upregulation of COX-2 by hypoxia
García Rodríguez et al., PLoS Med 2007 (Coronary Disease...) : Furthermore, estrogen confers atheroprotection via COX-2 dependent PGI2 in mice, raising the possibility that COX inhibitors may undermine the cardioprotection, suggested by observational studies, of endogenous or exogenous estrogens
Tan et al., J Immunol 2007 : Histamine induced increases in PGI ( 2 ) and PGE ( 2 ) production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production
Lee et al., J Immunol 2008 : Furthermore, the up-regulation of PGE ( 2 ) and PGI ( 2 ) production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor
Martínez-González et al., J Nutr 2008 : Therefore, oleanolic acid contributes to vascular homeostasis by inducing PGI2 release in a Cox-2 dependent manner
Araujo et al., American journal of physiology. Renal physiology 2010 (Hypertension) : Acute infusion of the vasoconstrictor ANG II increases COX-2 dependent PGE ( 2 ) and PGI ( 2 )
Leyva et al., Lung 2010 : PGI ( 2 ) release was mediated by cyclooxygenase-2 (COX-2) and vitronectin receptor (VNR)
Deacon et al., J Biol Chem 2010 (Vascular Diseases) : Amphiregulin, follistatin, and inhibin-beta-A and epiregulin were activated by an autocrine loop involving cPLA2, arachidonic acid release, COX-2 dependent PGI ( 2 ) synthesis, and IP receptor linked elevation of cAMP leading to CRE transcription activation
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Dovizio et al., J Pharmacol Exp Ther 2012 (Adenomatous Polyposis Coli) : Thus, a profound inhibition of COX-2 dependent PGI ( 2 ) might be associated with changes in circulating markers of angiogenesis
Przygodzki et al., Eur J Pharmacol 2013 (Diabetes Mellitus) : However, COX-2 activity significantly contributed to PGI ( 2 ) synthesis in healthy rats, with prostacyclin secretion being two-fold decreased by NS-398
Sakata et al., Thromb Res 2013 (Carotid Artery Thrombosis...) : Aspirin inhibits both the cyclooxygenase (COX)-1 dependent production of thromboxane A2 ( TXA2 ) in platelets and COX-2 dependent production of anti-aggregatory prostaglandin I2 (PGI2) in vessel walls, resulting in `` aspirin dilemma. ''