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HIPK1 — TNF

Text-mined interactions from Literome

Li et al., J Biol Chem 2005 : Our study suggests that TNFalpha induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha induced ASK1-JNK/p38 activation
Li et al., Cell Death Differ 2008 : SENP1 mediates TNF induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1 dependent apoptosis ... Furthermore, the wild-type form of SENP1 enhances, whereas the catalytic-inactive mutant form or siRNA of SENP1 blocks, TNF induced desumoylation and cytoplasmic translocation of HIPK1 as well as TNF induced ASK1-JNK activation ... We conclude that SENP1 mediates TNF induced desumoylation and translocation of HIPK1 , leading to an enhanced ASK1 dependent apoptosis