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NCBP1 — PARN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Balatsos et al., J Biol Chem 2006
:
Here we have investigated how the
cap binding complex (CBC) affects human
PARN activity ... We showed that
CBC , via its 80-kDa subunit ( CBP80 ),
inhibited PARN , suggesting that CBC can regulate mRNA deadenylation ... The
CBC mediated
inhibition of
PARN was cap independent, and in keeping with this, the CBP80 subunit alone inhibited PARN ... Based on our data, we have proposed a model for
CBC mediated regulation of
PARN , which relies on an interaction between CBP80 and PARN
Cevher et al., EMBO J 2010
:
Extending these results, we found that the tumour suppressor BARD1, which is involved in the UV-induced inhibition of 3 ' cleavage, strongly activates deadenylation by PARN in the presence of CstF-50, and that CstF-50/BARD1 can revert the
cap binding protein-80 (CBP80) mediated inhibition of
PARN activity