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CTSB — IL1A

Text-mined interactions from Literome

Bauer et al., Gut 2010 (Colitis...) : Moreover, IL-1beta secretion was dependent on phagocytosis, lysosomal maturation, cathepsin B and L, and reactive oxygen species ( ROS )
Shi et al., Anesth Analg 2011 (Pain) : Finally, we determined whether neuropeptide stimulated IL-1ß production required activation of caspase-1 and cathepsin B
Rahman et al., J Virol 2011 (Poxviridae Infections...) : Activation of the NLRP3 inflammasome and secretion of IL-1ß was also dependent on the release of cathepsin B and production of reactive oxygen species ( ROS )
Meunier et al., Nanomedicine 2012 : Moreover, inhibition of lysosomal acidification or cathepsin-B activation reduces DWCNT induced IL-1ß secretion, suggesting that Nlrp3 inflammasome activation occurs via lysosomal destabilization
Zheng et al., PloS one 2012 (Necrosis...) : IL-1ß secretion was reduced in the presence of cathepsin B inhibitors, suggesting that activation of caspase-1 requires cathepsin B activity
Caicedo et al., J Orthop Res 2013 : CoCrMo-alloy particle-size induced IL-1ß production was dependent on the lysosomal protease Cathepsin B , further supporting lysosomal destabilization as causative in inflammation
Lage et al., Proc Natl Acad Sci U S A 2013 (Salmonella Infections) : Moreover, cathepsin B contributes to NAIP5/NLRC4 inflammasome induced pyroptosis and IL-1a and IL-1ß production in response to cytosolic flagellin