Tam et al., Biochem Pharmacol 2007
:
IL-1alpha increased the phosphorylation of both PKR and eIF2alpha, and nanomolar concentrations of PKR inhibitor suppressed the IL-1alpha induced changes in phosphorylation
Couturier et al., Curr Alzheimer Res 2012
(Alzheimer Disease...) :
Our results showed that PKR inhibition prevented the NF-?B activation and production of tumor necrosis factor alpha ( TNFa ) and interleukin (IL)-1ß at 12 months of age without decrease of Aß42 levels and memory deficits
Lu et al., Nature 2012
(Escherichia coli Infections...) :
PKR deficiency significantly inhibited the secretion of IL-1ß , IL-18 and HMGB1 in E. coli induced peritonitis