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ANG — PIK3R1
Text-mined interactions from Literome
Yano et al., J Biol Chem 2007
:
ANG II
induced a significant increase in
PI3K activity, which was abolished by co-treatment with losartan or 2',5'-dideoxyadenosine ( 2',5'-DOA, an adenylyl cyclase inhibitor ) but not by PD123319 ( an AT-2R antagonist ) or H89 ( a protein kinase A (PKA) inhibitor )
Giani et al., Am J Physiol Heart Circ Physiol 2007
:
The specific JAK2 inhibitor AG-490 blocked
ANG- ( 1-7 ) -induced JAK2 and IRS-1 phosphorylation but had no effect on ANG- ( 1-7 ) -induced phosphorylation of Akt, indicating that activation of cardiac Akt by ANG- ( 1-7 ) appears not to involve the recruitment of JAK2 but proceeds through the receptor Mas and
involves PI3K