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FGF2 — IFI27
Text-mined interactions from Literome
Kim et al., Angiogenesis 2005
:
In Western blot analysis,
bFGF induced cytoplasmic translocation of p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) and phosphorylation of p27 ( Kip1 ) but rk-2 treatment
inhibited translocation of p21 ( Waf1/Cip1 ) and
p27 ( Kip1 ) from nucleus to cytoplasm and phosphorylation of p27 ( Kip1 )
Lee et al., J Biol Chem 2007
:
FGF-2 stimulation dramatically increased p27 phosphorylation at Ser-10 and Thr-187 using differential kinetics, and the FGF-2 induced
p27 phosphorylation was completely
blocked at both sites by LY294002 ... We determined the physical and biochemical interaction of
p27 with the Cdk2-cyclin E complex in
response to
FGF-2 stimulation
Lee et al., Invest Ophthalmol Vis Sci 2011
:
ERK1/2 was also involved in
FGF-2 stimulated CEC proliferation and phosphorylation of
p27 at Ser10 and Thr187 in parallel to phosphatidylinositol (PI) 3-kinase
Lee et al., Invest Ophthalmol Vis Sci 2011
:
Using immunoblotting, the authors showed that
FGF-2 induced phosphorylation of
p27 at both serine 10 ( Ser10 ) and threonine 187 ( Thr187 ) sites
Santarén et al., EMBO J 1986
:
Platelet derived growth factor and
fibroblast growth factor strongly induce p35 and p69 but weakly
induce p27 and p38