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CCND1 — PAK4

Text-mined interactions from Literome

Nheu et al., Cell cycle (Georgetown, Tex.) 2004 : PAK is essential for RAS induced upregulation of cyclin D1 during the G1 to S transition
Fernandez-Zapico et al., Cancer Cell 2005 (Adenocarcinoma...) : Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1 , and NF-kappaB and involve cyclin D1 upregulation
Xiao et al., Mol Cell Biol 2005 (Mesothelioma) : Furthermore, PAK1 stimulated cyclin D1 promoter activity was repressed by cotransfection of NF2, and PAK activity was inhibited by expression of merlin ... Collectively, our data indicate that merlin exerts its antiproliferative effect, at least in part, via repression of PAK induced cyclin D1 expression, suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors