Gene interactions and pathways from curated databases and text-mining

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CFP — IFNG

Text-mined interactions from Literome

Moraes et al., Rev Port Cardiol 1999 (Takayasu Arteritis) : We have shown reactivity of peripheral lymphocytes to HSP 65 kDa and a trend towards higher production of IFN-gamma in response to ST-CFP and MT-CFP in a patient with TA
Arend et al., Int J Tuberc Lung Dis 2001 (Tuberculosis, Pulmonary) : IFN-gamma production in response to ESAT-6 and CFP-10 by peripheral blood mononuclear cells from these patients was evaluated before and during anti-tuberculosis treatment ... In all five patients, IFN-gamma responses to ESAT-6 and/or CFP-10 were above the cut-off level defined in a previous study
Elliott et al., Trans R Soc Trop Med Hyg 2003 (HIV Infections...) : Among those with schistosomiasis, IFN-gamma and IL-2 responses to CFP , and IL-2 and IL-4 responses to PHA declined but there was a sustained increase in cytokine responses to SWA following treatment
Elliott et al., BMC infectious diseases 2005 (Hookworm Infections...) : Maternal hookworm was associated with reduced maternal IFN-gamma responses to CFP ( adjusted odds ratio for IFN-gamma > median response : 0.14 ( 95 % confidence interval 0.02-0.83, p = 0.021 )
Pai et al., Journal of occupational medicine and toxicology (London, England) 2006 : IFN-gamma responses to ESAT-6, CFP-10 and TB7.7 peptides were measured using ELISA, and IFN-gamma > /=0.35 IU/mL was used to define a positive QFT-G test result
Tavares et al., Microbiol Immunol 2007 (Tuberculosis) : Similar to the ESAT-6/CFP-10 combination, IFN-gamma response to 38 kDa/CFP-10 showed an increased tendency in treated patients, although not signifi-cant ( P = 0.16 )
Fox et al., Trans R Soc Trop Med Hyg 2007 (Tuberculosis, Pulmonary) : Commercial tests measuring IFN-gamma responses to ESAT-6 and CFP-10 are available for diagnosing Mycobacterium tuberculosis infection
Ruhwald et al., Microbes Infect 2007 (Tuberculosis) : CXCL10, IL-2, and IFN-gamma responses to stimulation with ESAT-6/CFP10/TB7.7 were assessed in 12 Quantiferon positive, 8 Quantiferon negative tuberculosis patients and 11 Quantiferon negative controls
Higuchi et al., Respirology 2008 (Tuberculosis) : Chemotherapy for Mycobacterium tuberculosis infection may decrease interferon (IFN)-gamma responses to early secretory antigenic target 6 and culture filtrate protein (CFP)-10 ; a reaction that could be useful to monitor the success of treatment
Wang et al., J Immunol 2009 : Recombinant ESAT-6, but not CFP10 , markedly inhibited IFN-gamma production by T cells stimulated with M. tuberculosis or with the combination of anti-CD3 and anti-CD28, in a dose dependent manner
Hasan et al., PloS one 2009 : ESAT6- and CFP10 induced IFNgamma was comparable between ECs and TB patients ... Both ESAT6- and CFP10 induced IFNgamma secretion was greater in LNTB than PTB
Ogata et al., Mod Rheumatol 2010 (Tuberculosis) : CFP-10 stimulated significant production of IFN-gamma ( 1.46 +/- 1.60 IU/ml ), and TCZ did not inhibit IFN-gamma production ( 1.51 +/- 1.77 IU/ml )
Samten et al., Tuberculosis (Edinb) 2009 : To address this question, we studied the effect of recombinant ESAT-6 and CFP10 on human primary T-cell IFN-gamma secretion and proliferation ... ESAT-6, but not CFP10 , inhibited IFN-gamma production by T cells stimulated with M. tuberculosis or with anti-CD3 plus anti-CD28, in a dose dependent manner ... Presence of CFP10 as part of the ESAT-6/CFP10 heterodimer did not affect ESAT-6 inhibition of T-cell IFN-gamma production
del Corral et al., PloS one 2009 (Tuberculosis) : IFNgamma response to CFP-10 , a biomarker of M. tuberculosis infection, tested positive in 66.3 % HHCs and 24.3 % from the SP ( OR = 6.07, p < 0.0001 ) ... CFP-10 induced IFNgamma production is useful to establish tuberculosis infection prevalence amongst HHC and identify those at highest risk of disease
Cho et al., J Infect 2010 (Tuberculosis, Osteoarticular) : In addition to conventional tests for TB, we used ELISPOT assays to measure the IFN-gamma response to ESAT-6 and CFP-10 in T-cells in samples of peripheral blood mononuclear cells ( PBMC )
Bussiere et al., J Pharmacol Exp Ther 1993 : In vitro addition of interleukin (IL)-6, IL-1 beta or interferon-gamma ( 0.5-50 U/ml ) attenuated the suppression of the PFC response in cells from morphine treated mice, whereas higher doses ( 100 U/ml ) restored completely the PFC response to control levels