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ARHGEF6 — PAK4
Pathways - manually collected, often from reviews:
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
utrophin (UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
utrophin (UTRN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
→
None
(modification, activates)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
→
None
(modification, activates)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
cortactin (CTTN)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
cortactin (CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1)
→
Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
KEGG Regulation of actin cytoskeleton:
PAK1/PAK2/PAK3/PAK4/PAK6/PAK7
→
ARHGEF6/ARHGEF7
(protein-protein, phosphorylation)
-
WikiPathways Regulation of Actin Cytoskeleton:
PAK1/PAK2/PAK3/PAK4/PAK6/PAK7
→
ARHGEF6/ARHGEF7
(activation)
Text-mined interactions from Literome
Bagrodia et al., J Biol Chem 1999
:
In cells, p50 ( Cool-1 ) suppresses Pak activation by upstream activators ; p85 ( Cool-1 ) has a permissive effect on Pak activation, and we now show that the closely related
Cool-2 stimulates
Pak kinase activity
Feng et al., J Biol Chem 2002
:
Three members of the Cool/Pix family have shown distinct regulatory activities : ( i ) p50 ( Cool-1 ) inhibits Cdc42/Rac stimulated PAK activity, ( ii ) p85 ( Cool-1 ) /beta-Pix has a permissive effect on Cdc42/Rac stimulated activity, and ( iii ) p90 ( Cool-2 )
/alpha-Pix strongly
activates PAK ... However, here we show that the Cat proteins bind to the carboxyl-terminal ends of p85 ( Cool-1 ) ( residues 523-546 ) and Cool-2 ( residues 647-670 ), and that the binding of Cat to Cool-2 in fact is not necessary for the
Cool-2 mediated activation of
PAK
Flanders et al., FEBS Lett 2003
(Breast Neoplasms) :
Expression of Cbl-b effectively blocks the ability of
Cool-2 to
stimulate PAK , thus providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation